ID   Y812_AQUAE              Reviewed;         368 AA.
AC   O66994;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Uncharacterized MscS family protein aq_812;
GN   OrderedLocusNames=aq_812;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family. {ECO:0000305}.
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DR   EMBL; AE000657; AAC06958.1; -; Genomic_DNA.
DR   PIR; G70370; G70370.
DR   RefSeq; NP_213555.1; NC_000918.1.
DR   RefSeq; WP_010880493.1; NC_000918.1.
DR   AlphaFoldDB; O66994; -.
DR   SMR; O66994; -.
DR   STRING; 224324.aq_812; -.
DR   EnsemblBacteria; AAC06958; AAC06958; aq_812.
DR   KEGG; aae:aq_812; -.
DR   PATRIC; fig|224324.8.peg.640; -.
DR   eggNOG; COG0668; Bacteria.
DR   HOGENOM; CLU_037945_0_4_0; -.
DR   InParanoid; O66994; -.
DR   OMA; LTIRMRW; -.
DR   OrthoDB; 1597438at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   Gene3D; 2.30.30.60; -; 1.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR006685; MscS_channel.
DR   InterPro; IPR011066; MscS_channel_C.
DR   InterPro; IPR006686; MscS_channel_CS.
DR   InterPro; IPR011014; MscS_channel_TM-2.
DR   InterPro; IPR023408; MscS_dom_sf.
DR   InterPro; IPR045042; YnaI-like.
DR   PANTHER; PTHR43634; PTHR43634; 1.
DR   Pfam; PF00924; MS_channel; 1.
DR   SUPFAM; SSF50182; SSF50182; 1.
DR   SUPFAM; SSF82689; SSF82689; 1.
DR   SUPFAM; SSF82861; SSF82861; 1.
DR   PROSITE; PS01246; UPF0003; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..368
FT                   /note="Uncharacterized MscS family protein aq_812"
FT                   /id="PRO_0000110244"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        144..164
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   368 AA;  42178 MW;  E63927534761871A CRC64;
     MEEILIWIKK LEKYLYALNA KVAGIPLYKI IIASAIMLFT LILRRLIAFL IVKILTKLTI
     RTKTDVDELI VKAFVKPFSY FIVVFGFYLS LLVLEVPKVY ADKFLKTFSL LILGWAIIRF
     LNLFHNKIVE FFVKVGGKDF AEEVGDFILK ILKAFVVVIV GASLLQEWGV NIGAILASVG
     LLGLAVSLAA KDTFENILSG LIILLDKPVK VGETVKVKDF MGSVEDIGLR STKIRTFDKS
     LVTIPNRDIV NNHVENFTRR NKRRVRFYIG VVYSTKREQL ENILKEIREL LKEHPGVAKD
     EKFYVYFENY GDSSLNILIQ YYANTNDYEE YLKIIEDINL KIMEIVEKNG SSFAFPSRSV
     YIEKMPKS