Y8206_DICDI
ID Y8206_DICDI Reviewed; 573 AA.
AC Q54T06;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Probable zinc transporter protein DDB_G0282067;
GN ORFNames=DDB_G0282067;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18590548; DOI=10.1186/1471-2180-8-109;
RA Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R.,
RA Ivens A., Martinez J.L., Escalante R.;
RT "Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common
RT and specific effects from PAO1 and PA14 strains.";
RL BMC Microbiol. 8:109-109(2008).
CC -!- FUNCTION: May be involved in zinc transport from the cytoplasm to
CC either intracellular organelles or extracellular spaces. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- INDUCTION: Down-regulated by Pseudomonas aeruginosa, PAO1 strain and
CC PA14 strain infection. {ECO:0000269|PubMed:18590548}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000044; EAL66455.1; -; Genomic_DNA.
DR RefSeq; XP_640445.1; XM_635353.1.
DR AlphaFoldDB; Q54T06; -.
DR SMR; Q54T06; -.
DR STRING; 44689.DDB0229454; -.
DR PaxDb; Q54T06; -.
DR EnsemblProtists; EAL66455; EAL66455; DDB_G0282067.
DR GeneID; 8623404; -.
DR KEGG; ddi:DDB_G0282067; -.
DR dictyBase; DDB_G0282067; zntB.
DR eggNOG; KOG1483; Eukaryota.
DR HOGENOM; CLU_013430_4_3_1; -.
DR InParanoid; Q54T06; -.
DR OMA; VICKHEC; -.
DR PhylomeDB; Q54T06; -.
DR Reactome; R-DDI-425410; Metal ion SLC transporters.
DR Reactome; R-DDI-435368; Zinc efflux and compartmentalization by the SLC30 family.
DR PRO; PR:Q54T06; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005794; C:Golgi apparatus; IDA:dictyBase.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0140221; C:pathogen-containing vacuole membrane; IDA:dictyBase.
DR GO; GO:0032010; C:phagolysosome; IDA:dictyBase.
DR GO; GO:0055037; C:recycling endosome; IDA:dictyBase.
DR GO; GO:0022890; F:inorganic cation transmembrane transporter activity; ISS:dictyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISS:dictyBase.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; ISS:dictyBase.
DR GO; GO:0042742; P:defense response to bacterium; IDA:dictyBase.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; IMP:dictyBase.
DR Gene3D; 1.20.1510.10; -; 2.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF160240; SSF160240; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 2: Evidence at transcript level;
KW Ion transport; Membrane; Metal-binding; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..573
FT /note="Probable zinc transporter protein DDB_G0282067"
FT /id="PRO_0000385370"
FT TOPO_DOM 1..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..85
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 147..161
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 183..380
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 402..411
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 433..573
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 190..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..275
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 573 AA; 63242 MW; 14080FAC904CF199 CRC64;
MYNKNNNNNN IIDDNDYDDD DDDYNYYNNN NYDYNENLIS KDTKKQKDLE KEPLSKSIAF
ISIGTLTLLY VIVELGAALY VGSLTLLSDG FHNLSDVVSL VIAWWAQKAA KRDSDNFMSY
GWARAEILGG LTNGCFLLSM SLYVALEAIP RFIRPEPMES GLIFMIVAGS GLAINILGTI
VFACTGMSHA HSHGGGGHSH GGGGGHSHGA EKEKKKEKHG HSHDGADKEK KKEKHGHGHS
HSTATTAVGI NSEEHNHDDH DHHDHSEESH GHSHGGEKKK EKKHGHSHSH GGGAAEGINI
NDEHDHDHEG HHDHSEENHG HSHGGSEKKK EKHGHGHSHD GGVEKKKEKH GHSHDGVEKK
KKKKKSSGTC LGMDLNMFGV FLHFLGDAIS SLFVLITGAV IHFTHGKWTE YIDPAVSLII
VIMIAATSAP LVKRCSMILL QKVPDDIDLD SIRYKIAKVE GVVSQHDLHV WQLVDGMTIA
SVHVGIEQGR EFQSIASKLR KIFHKEGIHS TSIQPEFLPI NSFTGGATSD PNFCIQNCVD
DCEEEWCCKK SADRIRMRNF NSKNSNIVDI NDI
