Y828_PYRHO
ID Y828_PYRHO Reviewed; 116 AA.
AC O58558;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Putative gamma-glutamylcyclotransferase PH0828;
DE EC=2.3.2.-;
GN OrderedLocusNames=PH0828;
OS Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS 100139 / OT-3).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=70601;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT "Complete sequence and gene organization of the genome of a hyper-
RT thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL DNA Res. 5:55-76(1998).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS), AND PROPOSED FUNCTION.
RX PubMed=15390261; DOI=10.1002/prot.20255;
RA Tajika Y., Sakai N., Tamura T., Yao M., Watanabe N., Tanaka I.;
RT "Crystal structure of hypothetical protein PH0828 from Pyrococcus
RT horikoshii.";
RL Proteins 57:862-865(2004).
CC -!- FUNCTION: Putative gamma-glutamylcyclotransferase.
CC -!- SIMILARITY: Belongs to the gamma-glutamylcyclotransferase family.
CC {ECO:0000305}.
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DR EMBL; BA000001; BAA29921.1; -; Genomic_DNA.
DR PIR; G71132; G71132.
DR RefSeq; WP_010884924.1; NC_000961.1.
DR PDB; 1V30; X-ray; 1.40 A; A=1-116.
DR PDBsum; 1V30; -.
DR AlphaFoldDB; O58558; -.
DR SMR; O58558; -.
DR STRING; 70601.3257238; -.
DR EnsemblBacteria; BAA29921; BAA29921; BAA29921.
DR GeneID; 1443159; -.
DR KEGG; pho:PH0828; -.
DR eggNOG; arCOG03271; Archaea.
DR OMA; FGRAILW; -.
DR OrthoDB; 114717at2157; -.
DR EvolutionaryTrace; O58558; -.
DR Proteomes; UP000000752; Chromosome.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd06661; GGCT_like; 1.
DR InterPro; IPR009288; AIG2-like_dom.
DR InterPro; IPR013024; GGCT-like.
DR InterPro; IPR036568; GGCT-like_sf.
DR Pfam; PF06094; GGACT; 1.
DR SUPFAM; SSF110857; SSF110857; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acyltransferase; Transferase.
FT CHAIN 1..116
FT /note="Putative gamma-glutamylcyclotransferase PH0828"
FT /id="PRO_0000184795"
FT ACT_SITE 76
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 13..16
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT STRAND 8..12
FT /evidence="ECO:0007829|PDB:1V30"
FT HELIX 23..26
FT /evidence="ECO:0007829|PDB:1V30"
FT STRAND 29..64
FT /evidence="ECO:0007829|PDB:1V30"
FT HELIX 66..72
FT /evidence="ECO:0007829|PDB:1V30"
FT HELIX 76..80
FT /evidence="ECO:0007829|PDB:1V30"
FT STRAND 81..86
FT /evidence="ECO:0007829|PDB:1V30"
FT STRAND 93..98
FT /evidence="ECO:0007829|PDB:1V30"
FT STRAND 104..106
FT /evidence="ECO:0007829|PDB:1V30"
SQ SEQUENCE 116 AA; 13669 MW; CBB41AC2F022FCC9 CRC64;
MSYKEKSVRI AVYGTLRKGK PLHWYLKGAK FLGEDWIEGY QLYFEYLPYA VKGKGKLKVE
VYEVDKETFE RINEIEIGTG YRLVEVSTKF GKAFLWEWGS KPRGKRIKSG DFDEIR