Y8295_DICDI
ID Y8295_DICDI Reviewed; 141 AA.
AC Q54YD2;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Putative phosphatidylglycerol/phosphatidylinositol transfer protein DDB_G0278295;
DE Flags: Precursor;
GN ORFNames=DDB_G0278295;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- FUNCTION: Catalyzes the intermembrane transfer of phosphatidylglycerol
CC and phosphatidylinositol. {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- INDUCTION: Down-regulated by phagocytic stimuli.
CC {ECO:0000269|PubMed:18559084}.
CC -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR EMBL; AAFI02000023; EAL68320.1; -; Genomic_DNA.
DR RefSeq; XP_642270.1; XM_637178.1.
DR AlphaFoldDB; Q54YD2; -.
DR SMR; Q54YD2; -.
DR STRING; 44689.DDB0205354; -.
DR PaxDb; Q54YD2; -.
DR EnsemblProtists; EAL68320; EAL68320; DDB_G0278295.
DR GeneID; 8621479; -.
DR KEGG; ddi:DDB_G0278295; -.
DR dictyBase; DDB_G0278295; -.
DR eggNOG; KOG4680; Eukaryota.
DR HOGENOM; CLU_097982_2_0_1; -.
DR InParanoid; Q54YD2; -.
DR OMA; RRFDVCE; -.
DR PhylomeDB; Q54YD2; -.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-8964038; LDL clearance.
DR PRO; PR:Q54YD2; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0015918; P:sterol transport; IBA:GO_Central.
DR Gene3D; 2.70.220.10; -; 1.
DR InterPro; IPR036846; GM2-AP_sf.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR003172; ML_dom.
DR InterPro; IPR039670; NPC2-like.
DR PANTHER; PTHR11306; PTHR11306; 1.
DR Pfam; PF02221; E1_DerP2_DerF2; 1.
DR SMART; SM00737; ML; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Lipid transport; Reference proteome; Signal; Transport.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..141
FT /note="Putative phosphatidylglycerol/phosphatidylinositol
FT transfer protein DDB_G0278295"
FT /id="PRO_0000389014"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 104
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 141 AA; 14968 MW; 26AC68251F26EFF1 CRC64;
MRLLLALFFV LALVSPSFTQ VWSNCGTAAD KFQITNVVLD PPTPVKGQDI TISASGILDE
TVTGGNVAVK VKYGFITLIN ENVSICSSQD PLACPIAAGD YQKNMTEMIP SDAPSGKYTG
NVVITDQNNA EIACIDVDIN L
