Y8444_DICDI
ID Y8444_DICDI Reviewed; 502 AA.
AC Q1ZXR0;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=TNF receptor-associated factor family protein DDB_G0268444;
GN ORFNames=DDB_G0268444;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18590548; DOI=10.1186/1471-2180-8-109;
RA Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R.,
RA Ivens A., Martinez J.L., Escalante R.;
RT "Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common
RT and specific effects from PAO1 and PA14 strains.";
RL BMC Microbiol. 8:109-109(2008).
CC -!- FUNCTION: Probable adapter protein and signal transducer that links
CC members of the tumor necrosis factor receptor family to different
CC signaling pathways by association with the receptor cytoplasmic domain
CC and kinases. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- INDUCTION: Down-regulated by Pseudomonas aeruginosa, PAO1 strain and
CC up-regulated by PA14 strain infection. {ECO:0000269|PubMed:18590548}.
CC -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000003; EAS66947.1; -; Genomic_DNA.
DR RefSeq; XP_001134485.1; XM_001134485.1.
DR AlphaFoldDB; Q1ZXR0; -.
DR SMR; Q1ZXR0; -.
DR STRING; 44689.DDB0232346; -.
DR PaxDb; Q1ZXR0; -.
DR PRIDE; Q1ZXR0; -.
DR EnsemblProtists; EAS66947; EAS66947; DDB_G0268444.
DR GeneID; 8616387; -.
DR KEGG; ddi:DDB_G0268444; -.
DR dictyBase; DDB_G0268444; trafN.
DR eggNOG; KOG0297; Eukaryota.
DR HOGENOM; CLU_040980_0_0_1; -.
DR InParanoid; Q1ZXR0; -.
DR OMA; CEFRLEY; -.
DR PhylomeDB; Q1ZXR0; -.
DR Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR PRO; PR:Q1ZXR0; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00121; MATH; 1.
DR Gene3D; 2.60.210.10; -; 1.
DR Gene3D; 3.30.40.10; -; 3.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR001293; Znf_TRAF.
DR PANTHER; PTHR10131; PTHR10131; 1.
DR Pfam; PF02176; zf-TRAF; 2.
DR PROSITE; PS50144; MATH; 1.
DR PROSITE; PS50145; ZF_TRAF; 2.
PE 2: Evidence at transcript level;
KW Coiled coil; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc;
KW Zinc-finger.
FT CHAIN 1..502
FT /note="TNF receptor-associated factor family protein
FT DDB_G0268444"
FT /id="PRO_0000393765"
FT DOMAIN 368..489
FT /note="MATH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT ZN_FING 28..68
FT /note="RING-type; degenerate"
FT ZN_FING 129..183
FT /note="TRAF-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT ZN_FING 185..243
FT /note="TRAF-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT COILED 261..295
FT /evidence="ECO:0000255"
SQ SEQUENCE 502 AA; 59834 MW; 02796F2E5BC34F2D CRC64;
MAEYTHYFIQ YNLTDIFYED VNIEKYSCSI CYESVYKKEI YQCKEIHWFC KTCWAESLFK
KKECMICRCI VKSISELSRN RFIEQDFLNI KVNCPNSFKY IDENKNNNNK IKDLENGCKD
IITIGEIEKH LKQCKFTHIK CKFIGCNKII RLNQVEKHEK EQCEFRLEYC RYCDTDGITS
RSLENHYKEC PKFIVKCSEN GCTVQLERSQ LESHIEKQCQ MVMIDCPYKI YGCEQSNRFP
KSNLTQHLSS INHTLAMGSM IESQSLQIKE TNIKYENLLN KINKLEQLET ESKCDQLYDK
FYQFESKIDK KLNNLQLDLY PKDNQQPQQK EQKEQKEQKE QQERIKFDDL FEKVSKVNSY
FINGCLLKYK NRWSISNYLT ESRKYRKITS PSFKIYDKKF KLVIYPQGKD DGSYTSLFLK
SDSINPIKVF YKFVLLNFKD ESKNLIFKNK SIMDKEKSVG CHYFIKSTEP GKKPEVWLKD
DSLVIDFSIE VNINNDIKPL ES
