ID   Y8469_DICDI             Reviewed;         715 AA.
AC   Q54Y18;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Bromodomain-containing protein DDB_G0278469;
GN   ORFNames=DDB_G0278469;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
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DR   EMBL; AAFI02000023; EAL68407.1; -; Genomic_DNA.
DR   RefSeq; XP_642384.1; XM_637292.1.
DR   AlphaFoldDB; Q54Y18; -.
DR   SMR; Q54Y18; -.
DR   STRING; 44689.DDB0220703; -.
DR   PaxDb; Q54Y18; -.
DR   EnsemblProtists; EAL68407; EAL68407; DDB_G0278469.
DR   GeneID; 8621589; -.
DR   KEGG; ddi:DDB_G0278469; -.
DR   dictyBase; DDB_G0278469; -.
DR   HOGENOM; CLU_380118_0_0_1; -.
DR   InParanoid; Q54Y18; -.
DR   PRO; PR:Q54Y18; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   CDD; cd00060; FHA; 1.
DR   Gene3D; 1.20.920.10; -; 1.
DR   InterPro; IPR001487; Bromodomain.
DR   InterPro; IPR036427; Bromodomain-like_sf.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   Pfam; PF00439; Bromodomain; 1.
DR   SUPFAM; SSF47370; SSF47370; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   PROSITE; PS50014; BROMODOMAIN_2; 1.
PE   4: Predicted;
KW   Bromodomain; Coiled coil; Reference proteome.
FT   CHAIN           1..715
FT                   /note="Bromodomain-containing protein DDB_G0278469"
FT                   /id="PRO_0000388243"
FT   DOMAIN          508..582
FT                   /note="Bromo"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT   REGION          18..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..425
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          653..715
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          322..368
FT                   /evidence="ECO:0000255"
FT   COILED          437..470
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        186..205
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..302
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        303..331
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        332..359
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..416
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        663..677
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        685..715
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  81828 MW;  C2BC11219118DD69 CRC64;
     MEDISTIKKL EGLSVHCEDN NNNNNNNNNK ENINNDDNNI NPNRNATSSL LKGNIQQVKK
     KKVFARLHLF NRDGTVKQIV EMRKYKFIIG SDQKSTDILI TRPGVYSNHA EIIYDKEVRK
     FYLNPLVDPS ISDTIRINFI PFINKKEVLG NNDIISIGLR AFRIEFFAPV YVDNLILPKN
     IQPQQQQQKQ QQQQQQQQQA PTAQKKLKQE VEHILTAATT TPTTTTTKPK KLKTAPPTTV
     ASSSTIPKTT TTKKQAIEQP SKSNLKSSQN KLSTTTTTTI TSKPPLNKSS IDGDTRSESS
     KALQGLKPKE QKKDIMKSLI SSKKANTHEE KEEGESEEEE EEEEEEEEEE EEEEEEEQLE
     DKQKQTKTPI SQNKSASSNI KPLSKTSKSN PPPLSAATKS NPVVKKITST TVTRTTKKAD
     TETKQEIKIT KSSTTTKQQT QEEIEQELKL ESIRKRIEQF INKFEKEIND NDFKDLDEGK
     RKIKESLDFI SKTKYEFQGT TSNPGDVEST PLDKWFKNIP YEDFVDSFKL KYYSIITEPV
     SITSILNKLK SGPNYQLAEV LKDFKQMLIN VTLYHKEPNE YWWISHQCNI QFYKSLLETG
     LITQDQYQIQ YQTSNNEIVK LDKTLNLVPK LVVVENNDED DNNDDEGSKK AVLVDEDEDE
     CLNNQNNPTT YDSDGDFVTK QSDQESDEES DEESDEESDE ERDQLSEEED QEATN