Y8495_DICDI
ID Y8495_DICDI Reviewed; 532 AA.
AC Q54IV4;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=SET and MYND domain-containing protein DDB_G0288495;
DE EC=2.1.1.-;
GN ORFNames=DDB_G0288495;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18590548; DOI=10.1186/1471-2180-8-109;
RA Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R.,
RA Ivens A., Martinez J.L., Escalante R.;
RT "Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common
RT and specific effects from PAO1 and PA14 strains.";
RL BMC Microbiol. 8:109-109(2008).
RN [3]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- FUNCTION: Probable methyltransferase. {ECO:0000250}.
CC -!- INDUCTION: Down-regulated by phagocytic stimuli and up-regulated by
CC Pseudomonas aeruginosa, PAO1 strain and PA14 strain infection.
CC {ECO:0000269|PubMed:18559084, ECO:0000269|PubMed:18590548}.
CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR EMBL; AAFI02000112; EAL63196.1; -; Genomic_DNA.
DR RefSeq; XP_636699.1; XM_631607.1.
DR AlphaFoldDB; Q54IV4; -.
DR STRING; 44689.DDB0187960; -.
DR PaxDb; Q54IV4; -.
DR EnsemblProtists; EAL63196; EAL63196; DDB_G0288495.
DR GeneID; 8626656; -.
DR KEGG; ddi:DDB_G0288495; -.
DR dictyBase; DDB_G0288495; smdA.
DR eggNOG; ENOG502RBX6; Eukaryota.
DR HOGENOM; CLU_512351_0_0_1; -.
DR InParanoid; Q54IV4; -.
DR OMA; ELECKWI; -.
DR Reactome; R-DDI-3214841; PKMTs methylate histone lysines.
DR PRO; PR:Q54IV4; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0034968; P:histone lysine methylation; IBA:GO_Central.
DR GO; GO:1901261; P:regulation of sorocarp spore cell differentiation; IMP:dictyBase.
DR Gene3D; 2.170.270.10; -; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR002893; Znf_MYND.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SSF82199; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS01360; ZF_MYND_1; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Metal-binding; Methyltransferase; Reference proteome;
KW S-adenosyl-L-methionine; Transferase; Zinc; Zinc-finger.
FT CHAIN 1..532
FT /note="SET and MYND domain-containing protein DDB_G0288495"
FT /id="PRO_0000389434"
FT DOMAIN 25..448
FT /note="SET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT ZN_FING 70..116
FT /note="MYND-type; degenerate"
FT REGION 204..234
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 199..240
FT /evidence="ECO:0000255"
FT COMPBIAS 207..223
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 532 AA; 62080 MW; 2C4B51E2C5C78F54 CRC64;
MISYEYCDSS DSFYFNDIQD FDFNPWIEVK SVSEKGRCVF SKKFIPKGTM VFRDIPYAAI
VDNQFKRNIC TTCFKILLES NRHNFQTCPS CFQVNYCSNY CKQYSKIETK HTELECKWIQ
DFTVSFKHQM AEDDRNIVLL VLKILARRIH EKQSTIFHNK PLTTNTFETC TSNNNNIDLL
PMIPNDIPDL IDHLDDYFIN SKNNNEFENE EEEEEEQEQK GEGEQEENEN NENNEKVKKK
VIIIDDNEKE KEEIKKFNKI WKNDFKRLIN IAKVIQIIID DSIDSLENIK CDYGFVDNQG
DTEMVDNSID PKGLDKLVDN LSSSDLNILR LLCKIRANYF GLWNSAYKPI PLNSIDDDDD
DNNNNKEKPN NDYLWCGSGV YLKLSLFNHS CFPNCTTLIE YNINKKNSNN NNGNNGNNNS
YGDTNQLTIS IITLRDIEEN QELLITYIPL NQKINDRVKS LKSNWLFQCD CKRCHFEKIN
ENQTEKIYKD SCCTNQKCSG GLLIPLEQNS TQGICRVCKN TYTLPTVFYP LK
