ID   Y849_MYCTU              Reviewed;         419 AA.
AC   P9WJX5; L0T7W9; O53861;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Uncharacterized MFS-type transporter Rv0849;
GN   OrderedLocusNames=Rv0849;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP43597.1; -; Genomic_DNA.
DR   PIR; A70814; A70814.
DR   RefSeq; NP_215364.1; NC_000962.3.
DR   RefSeq; WP_003404402.1; NZ_NVQJ01000040.1.
DR   AlphaFoldDB; P9WJX5; -.
DR   SMR; P9WJX5; -.
DR   STRING; 83332.Rv0849; -.
DR   PaxDb; P9WJX5; -.
DR   DNASU; 885111; -.
DR   GeneID; 885111; -.
DR   KEGG; mtu:Rv0849; -.
DR   TubercuList; Rv0849; -.
DR   eggNOG; COG2814; Bacteria.
DR   OMA; NHFQVTT; -.
DR   PhylomeDB; P9WJX5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..419
FT                   /note="Uncharacterized MFS-type transporter Rv0849"
FT                   /id="PRO_0000390682"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        213..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        351..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   419 AA;  44514 MW;  E97034876F12CB50 CRC64;
     MGARAIFRGF NRPSRVLMIN QFGINIGFYM LMPYLADYLA GPLGLAAWAV GLVMGVRNFS
     QQGMFFVGGT LADRFGYKPL IIAGCLIRTG GFALLVVAQS LPSVLIAAAA TGFAGALFNP
     AVRGYLAAEA GERKIEAFAM FNVFYQSGIL LGPLVGLVLL ALDFRITVLA AAGVFGLLTV
     AQLVALPQHR ADSEREKTSI LQDWRVVVRN RPFLTLAAAM TGCYALSFQI YLALPMQASI
     LMPRNQYLLI AAMFAVSGLV AVGGQLRITR WFAVRWGAER SLVVGATILA ASFIPVAVIP
     NGQRFGVAVA VMALVLSASL LAVASAALFP FEMRAVVALS GDRLVATHYG FYSTIVGVGV
     LVGNLAIGSL MSAARRLNTD EIVWGGLILV GIVAVAGLRR LDTFTSGSQN MTGRWAAPR