ID   Y8514_DICDI             Reviewed;         427 AA.
AC   Q54NN4;
DT   20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=TNF receptor-associated factor family protein DDB_G0285149;
GN   ORFNames=DDB_G0285149;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable adapter protein and signal transducer that links
CC       members of the tumor necrosis factor receptor family to different
CC       signaling pathways by association with the receptor cytoplasmic domain
CC       and kinases. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
CC   -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000074; EAL64887.1; -; Genomic_DNA.
DR   RefSeq; XP_639882.1; XM_634790.1.
DR   AlphaFoldDB; Q54NN4; -.
DR   SMR; Q54NN4; -.
DR   STRING; 44689.DDB0237661; -.
DR   PaxDb; Q54NN4; -.
DR   EnsemblProtists; EAL64887; EAL64887; DDB_G0285149.
DR   GeneID; 8624953; -.
DR   KEGG; ddi:DDB_G0285149; -.
DR   dictyBase; DDB_G0285149; trafB.
DR   eggNOG; KOG0297; Eukaryota.
DR   HOGENOM; CLU_040980_0_0_1; -.
DR   InParanoid; Q54NN4; -.
DR   OMA; FASCENI; -.
DR   PhylomeDB; Q54NN4; -.
DR   Reactome; R-DDI-5689880; Ub-specific processing proteases.
DR   PRO; PR:Q54NN4; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00121; MATH; 1.
DR   Gene3D; 2.60.210.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 3.
DR   InterPro; IPR002083; MATH/TRAF_dom.
DR   InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
DR   InterPro; IPR008974; TRAF-like.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001293; Znf_TRAF.
DR   PANTHER; PTHR10131; PTHR10131; 1.
DR   Pfam; PF00917; MATH; 1.
DR   Pfam; PF02176; zf-TRAF; 1.
DR   PROSITE; PS50144; MATH; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
DR   PROSITE; PS50145; ZF_TRAF; 2.
PE   3: Inferred from homology;
KW   Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..427
FT                   /note="TNF receptor-associated factor family protein
FT                   DDB_G0285149"
FT                   /id="PRO_0000393753"
FT   DOMAIN          284..415
FT                   /note="MATH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
FT   ZN_FING         20..65
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   ZN_FING         122..178
FT                   /note="TRAF-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   ZN_FING         178..234
FT                   /note="TRAF-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
SQ   SEQUENCE   427 AA;  50087 MW;  4D954CF632592046 CRC64;
     MTEFKISDLL VKPLSESFSC IVCTDLLSES HDKIQVNQCP HGHCLCSDCW TKQIENKKKE
     CPICRAKVKL EFLSRNLFLE SEFKKKKVYC KYQYKEEKED GKIIKDEENG CKDIIRIEEM
     ETHFKNCQYA FINCPNGDEC KINSRFRKNQ LEEHNKSCEY LKVPCQYCKT PIAKINKDHL
     ESECQSYKIK CTHCKLEMLR MELSEHLEVC PEMTIQCKYK EGGCQVSFQR KHQANHLASE
     NNHIGFIQNI IDQHRILLDE SDRCFKRLKC SHETLEKRLT NINKYSNQWV IENWMQKVID
     IPNDEVTSTK RVSCPMFYFN SRKYNVSCFP NGFTPANKDY ISLYLHLHEA SPNINIKFSF
     EIVNSDPTKS IKKEKNSYFQ NDKGIGWEKF AECKTINTLG EGFVVGNKLT IKFEIEIPQT
     IDPLTTK