ID   CAST2_XENLA             Reviewed;         329 AA.
AC   Q6DDW7;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Cytosolic arginine sensor for mTORC1 subunit 2 {ECO:0000250|UniProtKB:A6NHX0};
DE   AltName: Full=GATS-like protein 2 {ECO:0000305};
GN   Name=castor2 {ECO:0000250|UniProtKB:A6NHX0};
GN   Synonyms=gatsl1, gatsl2 {ECO:0000250|UniProtKB:A6NHX0};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a negative regulator of the TORC1 signaling
CC       pathway. {ECO:0000250|UniProtKB:A6NHX0}.
CC   -!- SUBUNIT: May form homodimers and heterodimers.
CC       {ECO:0000250|UniProtKB:A6NHX0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:A6NHX0}.
CC   -!- SIMILARITY: Belongs to the GATS family. {ECO:0000305}.
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DR   EMBL; BC077385; AAH77385.1; -; mRNA.
DR   RefSeq; NP_001086743.1; NM_001093274.1.
DR   AlphaFoldDB; Q6DDW7; -.
DR   SMR; Q6DDW7; -.
DR   MaxQB; Q6DDW7; -.
DR   DNASU; 446578; -.
DR   GeneID; 446578; -.
DR   KEGG; xla:446578; -.
DR   CTD; 446578; -.
DR   Xenbase; XB-GENE-949512; castor2.L.
DR   OrthoDB; 1166424at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 446578; Expressed in heart and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; ISS:UniProtKB.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR040778; CASTOR1_N.
DR   InterPro; IPR027795; CASTOR_ACT_dom.
DR   InterPro; IPR026249; CASTOR_fam.
DR   Pfam; PF13840; ACT_7; 2.
DR   Pfam; PF18700; Castor1_N; 1.
DR   PRINTS; PR02078; GATSLIKEFMLY.
DR   SUPFAM; SSF55021; SSF55021; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..329
FT                   /note="Cytosolic arginine sensor for mTORC1 subunit 2"
FT                   /id="PRO_0000325894"
FT   DOMAIN          72..139
FT                   /note="ACT 1"
FT   DOMAIN          262..322
FT                   /note="ACT 2"
SQ   SEQUENCE   329 AA;  36173 MW;  0F84C5BF99DAC915 CRC64;
     MELHILEHRL KVASIAKENI QLFTYGLIKL AFLSSKTRCK FFSLTETPED YTIIVDEEGF
     LELPSSEHLS VADATWLALN VVSGGGSSSS SQPIGVTKIA KSVIAPLADQ NISVFMLSTY
     QTDFILVRER DLPFVMHTLA AEFTILQVVN GETVAADNLG VTNGFVKPKL VQRPVIHPLS
     SPSNMFCVTS LDPYTLPTVT TLLMDVMFYS NGVKDSVVGS EEPDHIRFFS FSLIEGYISL
     VMDVQTQQRF PSNLLFTSAS GELWKMVRIG GQPLGFDECG IVAQISEPLA AADIPAYYIS
     TFKFDHALVP EENINGVINA LQVSQAEKH