ID   Y854_HAEIN              Reviewed;         253 AA.
AC   P44061;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Probable heme oxygenase HI_0854 {ECO:0000305};
DE            EC=1.14.99.- {ECO:0000250|UniProtKB:O25087};
GN   OrderedLocusNames=HI_0854;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA   Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- FUNCTION: Involved in heme iron utilization. Catalyzes the degradation
CC       of heme to biliverdin, with the release of iron and carbon monoxide.
CC       {ECO:0000250|UniProtKB:O25087}.
CC   -!- SIMILARITY: Belongs to the heme oxygenase HugZ/HutZ family.
CC       {ECO:0000305}.
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DR   EMBL; L42023; AAC22513.1; -; Genomic_DNA.
DR   PIR; G64014; G64014.
DR   RefSeq; NP_439014.1; NC_000907.1.
DR   RefSeq; WP_005693201.1; NC_000907.1.
DR   AlphaFoldDB; P44061; -.
DR   SMR; P44061; -.
DR   STRING; 71421.HI_0854; -.
DR   EnsemblBacteria; AAC22513; AAC22513; HI_0854.
DR   KEGG; hin:HI_0854; -.
DR   PATRIC; fig|71421.8.peg.895; -.
DR   eggNOG; COG0748; Bacteria.
DR   HOGENOM; CLU_093808_0_0_6; -.
DR   OMA; NNPHNVE; -.
DR   PhylomeDB; P44061; -.
DR   BioCyc; HINF71421:G1GJ1-894-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0070967; F:coenzyme F420 binding; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016627; F:oxidoreductase activity, acting on the CH-CH group of donors; IBA:GO_Central.
DR   Gene3D; 2.30.110.10; -; 1.
DR   Gene3D; 3.20.180.10; -; 1.
DR   InterPro; IPR019595; DUF2470.
DR   InterPro; IPR037119; Haem_oxidase_HugZ-like_sf.
DR   InterPro; IPR026324; Haem_oxygenase_HugZ.
DR   InterPro; IPR011576; Pyridox_Oxase_put.
DR   InterPro; IPR012349; Split_barrel_FMN-bd.
DR   Pfam; PF10615; DUF2470; 1.
DR   Pfam; PF01243; Putative_PNPOx; 1.
DR   TIGRFAMs; TIGR04109; heme_ox_HugZ; 1.
PE   1: Evidence at protein level;
KW   Heme; Iron; Metal-binding; Oxidoreductase; Reference proteome.
FT   CHAIN           1..253
FT                   /note="Probable heme oxygenase HI_0854"
FT                   /id="PRO_0000077961"
FT   BINDING         247
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250|UniProtKB:O25087"
SQ   SEQUENCE   253 AA;  28840 MW;  D76B49B662C5EA10 CRC64;
     MDFNRIITHM NDHHQDDMAV LCKKFGGEKE ITDVTLVNVD FAGLDFKYNG GKTLRVEFPQ
     QADAGSIKQV IINLCVENKP VANYDRIKAK IDEFRQEFKS CVLSTLDKDG LPMASYAPII
     FFDGKYYIYI SAIAEHYENL KRNPNQVEVM FLEDENKAKS IIVRTRLRYK ASARFIPRED
     PIVEKVLDKL AETMNDVGGI KTIREFTDFD LVELTFGTGR FVRGFGQAYL IDANGEISHI
     GVKGNPHEKE SDK