ID   CAST2_XENTR             Reviewed;         329 AA.
AC   Q63ZZ8;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Cytosolic arginine sensor for mTORC1 subunit 2 {ECO:0000250|UniProtKB:A6NHX0};
DE   AltName: Full=GATS-like protein 2 {ECO:0000305};
GN   Name=castor2 {ECO:0000250|UniProtKB:A6NHX0};
GN   Synonyms=gatsl1, gatsl2 {ECO:0000250|UniProtKB:A6NHX0};
GN   ORFNames=TNeu115k14.1 {ECO:0000312|EMBL:CAJ82710.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a negative regulator of the TORC1 signaling
CC       pathway. {ECO:0000250|UniProtKB:A6NHX0}.
CC   -!- SUBUNIT: May form homodimers and heterodimers.
CC       {ECO:0000250|UniProtKB:A6NHX0}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:A6NHX0}.
CC   -!- SIMILARITY: Belongs to the GATS family. {ECO:0000305}.
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DR   EMBL; CR760105; CAJ82710.1; -; mRNA.
DR   EMBL; BC082733; AAH82733.1; -; mRNA.
DR   RefSeq; NP_001011019.1; NM_001011019.1.
DR   AlphaFoldDB; Q63ZZ8; -.
DR   SMR; Q63ZZ8; -.
DR   STRING; 8364.ENSXETP00000060383; -.
DR   PaxDb; Q63ZZ8; -.
DR   Ensembl; ENSXETT00000039957; ENSXETP00000039957; ENSXETG00000018449.
DR   GeneID; 496428; -.
DR   KEGG; xtr:496428; -.
DR   CTD; 729438; -.
DR   Xenbase; XB-GENE-949506; castor2.
DR   eggNOG; ENOG502QV83; Eukaryota.
DR   HOGENOM; CLU_057799_0_0_1; -.
DR   InParanoid; Q63ZZ8; -.
DR   OrthoDB; 1166424at2759; -.
DR   PhylomeDB; Q63ZZ8; -.
DR   Reactome; R-XTR-9639288; Amino acids regulate mTORC1.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000018449; Expressed in testis and 13 other tissues.
DR   ExpressionAtlas; Q63ZZ8; differential.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:1903577; P:cellular response to L-arginine; IBA:GO_Central.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; ISS:UniProtKB.
DR   GO; GO:1902531; P:regulation of intracellular signal transduction; IBA:GO_Central.
DR   InterPro; IPR045865; ACT-like_dom_sf.
DR   InterPro; IPR040778; CASTOR1_N.
DR   InterPro; IPR027795; CASTOR_ACT_dom.
DR   InterPro; IPR026249; CASTOR_fam.
DR   Pfam; PF13840; ACT_7; 2.
DR   Pfam; PF18700; Castor1_N; 1.
DR   PRINTS; PR02078; GATSLIKEFMLY.
DR   SUPFAM; SSF55021; SSF55021; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..329
FT                   /note="Cytosolic arginine sensor for mTORC1 subunit 2"
FT                   /id="PRO_0000325895"
FT   DOMAIN          72..139
FT                   /note="ACT 1"
FT   DOMAIN          262..322
FT                   /note="ACT 2"
SQ   SEQUENCE   329 AA;  36114 MW;  2B1735836A15F5E5 CRC64;
     MELHILEHRL KVASIAKENI QLFTYGLIKL AFLSSKTRCK FFSLTETPED YTIIVDEEGF
     LELPSSEHLS VADATWLALN VVSGGGSSSS SQPIGVTKIA KSVIAPLADQ NISVFMLSTY
     QTDFILVRER DLPFVMHTLA AEFTILQVVN GETVAADNLG VTNGFVKPKL VQRPVIHPLS
     SPSNMFCVTS LDPYTLPTVT TLLMDVMFYS NGVKDSVVGS EEPGHIRFFS FSLIEGYISL
     VMDVQTQQRF PSNLLFTSAS GELWKMVRIG GQPLGFDECG IVAQISEPLA AADIPAYYIS
     TFKFDHALVP EENINGVINA LQVSQAEKH