CAST3_HUMAN
ID CAST3_HUMAN Reviewed; 163 AA.
AC Q8NAP1; D6W5V0; Q68D93; Q6P198; Q6PII7; Q7Z720; Q86UK9;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Putative protein CASTOR 3 {ECO:0000305};
DE AltName: Full=STAG3 opposite strand transcript protein {ECO:0000305};
GN Name=CASTOR3 {ECO:0000312|HGNC:HGNC:29954};
GN Synonyms=GATS {ECO:0000312|HGNC:HGNC:29954}, STAG3OS;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Hippocampus, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Cerebellum;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Eye, PNS, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the GATS family. {ECO:0000305}.
CC -!- CAUTION: Product of a dubious CDS prediction. The transcript contains
CC several 3' non-coding exons. May be produced at very low levels due to
CC a premature stop codon in the mRNA, leading to nonsense-mediated mRNA
CC decay. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH33723.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH53367.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH65200.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK092358; BAC03870.1; -; mRNA.
DR EMBL; AK290039; BAF82728.1; -; mRNA.
DR EMBL; AK290237; BAF82926.1; -; mRNA.
DR EMBL; AK290510; BAF83199.1; -; mRNA.
DR EMBL; CR749506; CAH18327.1; -; mRNA.
DR EMBL; CH471091; EAW76563.1; -; Genomic_DNA.
DR EMBL; CH471091; EAW76564.1; -; Genomic_DNA.
DR EMBL; CH471091; EAW76565.1; -; Genomic_DNA.
DR EMBL; BC033723; AAH33723.1; ALT_INIT; mRNA.
DR EMBL; BC044886; AAH44886.2; -; mRNA.
DR EMBL; BC053367; AAH53367.1; ALT_INIT; mRNA.
DR EMBL; BC065200; AAH65200.1; ALT_INIT; mRNA.
DR EMBL; BC090867; AAH90867.1; -; mRNA.
DR RefSeq; NP_849153.3; NM_178831.6.
DR AlphaFoldDB; Q8NAP1; -.
DR SMR; Q8NAP1; -.
DR BioGRID; 131583; 21.
DR IntAct; Q8NAP1; 6.
DR STRING; 9606.ENSP00000389760; -.
DR iPTMnet; Q8NAP1; -.
DR PhosphoSitePlus; Q8NAP1; -.
DR BioMuta; GATS; -.
DR DMDM; 74729973; -.
DR MassIVE; Q8NAP1; -.
DR PaxDb; Q8NAP1; -.
DR PeptideAtlas; Q8NAP1; -.
DR PRIDE; Q8NAP1; -.
DR DNASU; 352954; -.
DR GeneID; 352954; -.
DR UCSC; uc003uua.5; human.
DR CTD; 352954; -.
DR DisGeNET; 352954; -.
DR GeneCards; CASTOR3; -.
DR HGNC; HGNC:29954; CASTOR3.
DR neXtProt; NX_Q8NAP1; -.
DR PharmGKB; PA164720213; -.
DR eggNOG; ENOG502QV83; Eukaryota.
DR HOGENOM; CLU_125526_0_0_1; -.
DR InParanoid; Q8NAP1; -.
DR OrthoDB; 1166424at2759; -.
DR PhylomeDB; Q8NAP1; -.
DR PathwayCommons; Q8NAP1; -.
DR SignaLink; Q8NAP1; -.
DR BioGRID-ORCS; 352954; 67 hits in 984 CRISPR screens.
DR ChiTaRS; CASTOR3; human.
DR GenomeRNAi; 352954; -.
DR Pharos; Q8NAP1; Tdark.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8NAP1; protein.
DR Genevisible; Q8NAP1; HS.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:1903577; P:cellular response to L-arginine; IBA:GO_Central.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:1902531; P:regulation of intracellular signal transduction; IBA:GO_Central.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR040778; CASTOR1_N.
DR InterPro; IPR027795; CASTOR_ACT_dom.
DR InterPro; IPR026249; CASTOR_fam.
DR Pfam; PF13840; ACT_7; 1.
DR Pfam; PF18700; Castor1_N; 1.
DR PRINTS; PR02078; GATSLIKEFMLY.
DR SUPFAM; SSF55021; SSF55021; 1.
PE 5: Uncertain;
KW Reference proteome.
FT CHAIN 1..163
FT /note="Putative protein CASTOR 3"
FT /id="PRO_0000325892"
FT CONFLICT 78
FT /note="E -> G (in Ref. 4; AAH44886)"
FT /evidence="ECO:0000305"
FT CONFLICT 82
FT /note="V -> A (in Ref. 2; CAH18327)"
FT /evidence="ECO:0000305"
FT CONFLICT 90
FT /note="L -> P (in Ref. 2; CAH18327)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 163 AA; 17846 MW; B9BDF3D07A30E637 CRC64;
MSCRGRGAGG RWNSTSWSTG CKLPASPRRV SRCSPTGLIK LAFLFSKTRC KFFSLTETPE
DYTIIVDEEG FLELPSSEHL SVADATWLAL NVVSGGGSFS SSQPIGMTKI AKSVIAPLAD
QNISVFMLST YQTDFILVLK RDLPFVTHTL SSEFTILWSV ARL
