ID   Y856_METTH              Reviewed;         454 AA.
AC   O26944;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Metalloprotease MTH_856;
DE            EC=3.4.-.-;
GN   OrderedLocusNames=MTH_856;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- FUNCTION: Probable metalloprotease. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase U62 family. {ECO:0000305}.
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DR   EMBL; AE000666; AAB85354.1; -; Genomic_DNA.
DR   PIR; C69214; C69214.
DR   RefSeq; WP_010876489.1; NC_000916.1.
DR   AlphaFoldDB; O26944; -.
DR   SMR; O26944; -.
DR   STRING; 187420.MTH_856; -.
DR   EnsemblBacteria; AAB85354; AAB85354; MTH_856.
DR   GeneID; 1471264; -.
DR   KEGG; mth:MTH_856; -.
DR   PATRIC; fig|187420.15.peg.841; -.
DR   HOGENOM; CLU_026425_1_2_2; -.
DR   OMA; SVFHDKM; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2290.10; -; 1.
DR   InterPro; IPR045569; Metalloprtase-TldD/E_C.
DR   InterPro; IPR045570; Metalloprtase-TldD/E_cen_dom.
DR   InterPro; IPR002510; Metalloprtase-TldD/E_N.
DR   InterPro; IPR025502; TldD.
DR   InterPro; IPR035068; TldD/PmbA_N.
DR   InterPro; IPR036059; TldD/PmbA_sf.
DR   Pfam; PF01523; PmbA_TldD; 1.
DR   Pfam; PF19289; PmbA_TldD_C; 1.
DR   Pfam; PF19290; PmbA_TldD_M; 1.
DR   PIRSF; PIRSF004919; TldD; 1.
DR   SUPFAM; SSF111283; SSF111283; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metalloprotease; Protease; Reference proteome.
FT   CHAIN           1..454
FT                   /note="Metalloprotease MTH_856"
FT                   /id="PRO_0000142365"
FT   REGION          92..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   454 AA;  48155 MW;  E624E34D8F2144E8 CRC64;
     MEIDTDYLGS ILMDIEDRVE YADIRAGTSR TSSILMKDGK LQEVKSGRAS GFRIRVLRNG
     SWGFAFTDEP SRLGEMALKA IKMTGSLRGD VQVGSGAPSV DKTMVRSSRP PSDVPAAEKR
     ELVSDAHHAA SVDGVVSTTV SYVDMESSSA FLNSEGSLIE MAETRVALFL NAVASDGSGI
     QFGHKSCGGT GGFEILERED IEELGRRTGE KAVRLLKASP PPSGRFDIVT DPELTGVFIH
     EALGHAAEAD LILQGDSILE GKLGEKIASE GVTIIDDPTI DGFGSYSYDA EGVRAAETVL
     VENGVLTSLL NSRETAFKLG LEPSGNARSA IGDQPIVRMS NTYLKPGDLS FDELIEDIRN
     GVYLRGSRGG QVDTGKGIFQ FNAAESFRIQ DGEIAEPVKD VSLSGNVLET LKNVDGVGSD
     FRLGIGFCGK SGQSVPVGDG GPHVRIRNAM VGGT