ID   Y859_TREPA              Reviewed;         494 AA.
AC   O83831; O83832;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 2.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=UPF0164 protein TP_0859/TP_0860;
DE   Flags: Precursor;
GN   OrderedLocusNames=TP_0859/TP_0860;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SIMILARITY: Belongs to the UPF0164 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC65832.1; Type=Frameshift; Note=Produces two separate ORFs.; Evidence={ECO:0000305};
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DR   EMBL; AE000520; AAC65831.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; AE000520; AAC65832.1; ALT_FRAME; Genomic_DNA.
DR   PIR; C71272; C71272.
DR   PIR; D71272; D71272.
DR   RefSeq; WP_014342835.1; NC_021490.2.
DR   AlphaFoldDB; O83831; -.
DR   IntAct; O83831; 1.
DR   STRING; 243276.TPANIC_0859; -.
DR   EnsemblBacteria; AAC65831; AAC65831; TP_0859.
DR   EnsemblBacteria; AAC65832; AAC65832; TP_0860.
DR   KEGG; tpa:TP_0859; -.
DR   KEGG; tpa:TP_0860; -.
DR   eggNOG; ENOG5033RFB; Bacteria.
DR   HOGENOM; CLU_1194462_0_0_12; -.
DR   Proteomes; UP000000811; Chromosome.
DR   InterPro; IPR005362; UPF0164.
DR   Pfam; PF03687; UPF0164; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal.
FT   SIGNAL          1..44
FT                   /evidence="ECO:0000255"
FT   CHAIN           45..494
FT                   /note="UPF0164 protein TP_0859/TP_0860"
FT                   /id="PRO_0000036219"
SQ   SEQUENCE   494 AA;  52883 MW;  5B419C60CCEAF840 CRC64;
     MVRRPCVSAA PVRVGGRLVF GFARVGSRGL CLGALLLSPR IVLAQHVADA PLGARGVVPR
     SSLPRRTRAA RATTLRSRGG VVSSRASGGT LVVTAQKPKV MARNDVDYRP LSLQAGGRQG
     SLDLVATATA DDASFFEANA AGSATIPRMT LAFFHTMRIS DSHIDVLSFV GRAGRTGYGV
     SARAFYPDMS SKTTGFVGIF NVSHAFSSAY RFKGVSVGAN LKVGYRHTRG GGSSQSKSSN
     GKENHHIVLT ADVGVRGAWT VSKNFGAHEP NLWAGVAFRN IGASINATNL HGNNGAGGSG
     GGGGGNGDGK PAHVTDSRVI LALAYQPVRY FLFGAGLEWL YNVGSIKAVN SLRYGAAFML
     FPLRQLAFSS SVVMKGMGPQ QVRASAGAEV QFSHVRCTAS YSYLWSATPT RPHYVSIGVA
     GFLKPVPEQP LWQEVYRSYL RGLRHYHAQR YAEAIAEWKR TLQQGVSFEP AREGIERATK
     LLQLNQKVHD FNIF