Y8602_DICDI
ID Y8602_DICDI Reviewed; 218 AA.
AC Q54ME0;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Uncharacterized protein DDB_G0286021;
DE Flags: Precursor;
GN ORFNames=DDB_G0286021;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP DEVELOPMENTAL STAGE [LARGE SCALE ANALYSIS].
RX PubMed=12963116; DOI=10.1016/s0925-4773(03)00136-9;
RA Muramoto T., Suzuki K., Shimizu H., Kohara Y., Kohriki E., Obara S.,
RA Tanaka Y., Urushihara H.;
RT "Construction of a gamete-enriched gene pool and RNAi-mediated functional
RT analysis in Dictyostelium discoideum.";
RL Mech. Dev. 120:965-975(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed in gametes.
CC {ECO:0000269|PubMed:12963116}.
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DR EMBL; AAFI02000085; EAL64389.1; -; Genomic_DNA.
DR RefSeq; XP_637894.1; XM_632802.1.
DR AlphaFoldDB; Q54ME0; -.
DR SMR; Q54ME0; -.
DR PaxDb; Q54ME0; -.
DR EnsemblProtists; EAL64389; EAL64389; DDB_G0286021.
DR GeneID; 8625404; -.
DR KEGG; ddi:DDB_G0286021; -.
DR dictyBase; DDB_G0286021; -.
DR eggNOG; ENOG502RHA4; Eukaryota.
DR HOGENOM; CLU_1268922_0_0_1; -.
DR InParanoid; Q54ME0; -.
DR OMA; NWMDNYG; -.
DR PhylomeDB; Q54ME0; -.
DR PRO; PR:Q54ME0; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR013201; Prot_inhib_I29.
DR Pfam; PF08246; Inhibitor_I29; 1.
DR SMART; SM00848; Inhibitor_I29; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..218
FT /note="Uncharacterized protein DDB_G0286021"
FT /id="PRO_0000393120"
FT TOPO_DOM 20..146
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..218
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 218 AA; 23710 MW; 7AA9DE6D328091E7 CRC64;
MKIIVLVLLI LGCSQLINSQ EVPSDSILFQ QFINWMDNYG IFYTSGDMQS KFKSWKSNVL
EIASLNSNLN VPDVLYTVTE TPVSNLRTLL DAEPTIVESY PGQDIQQFEV NQFSDLTASE
FSNIYAGADA SLAISEVAAS TLSTGAIVGI AVGGSVALIG ATAATVLIVK KKRQNKKPQV
SEPIATTQDV KMKPTNGIDL LNRTENQHRS ITARAFYS