ID   Y865_STRP1              Reviewed;         282 AA.
AC   Q9A0A6; Q48ZC8;
DT   28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=DegV domain-containing protein SPy_0865/M5005_Spy0672;
GN   OrderedLocusNames=SPy_0865, M5005_Spy0672;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- FUNCTION: May bind long-chain fatty acids, such as palmitate, and may
CC       play a role in lipid transport or fatty acid metabolism. {ECO:0000250}.
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DR   EMBL; AE004092; AAK33788.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51290.1; -; Genomic_DNA.
DR   RefSeq; NP_269067.1; NC_002737.2.
DR   AlphaFoldDB; Q9A0A6; -.
DR   SMR; Q9A0A6; -.
DR   STRING; 1314.HKU360_00682; -.
DR   PaxDb; Q9A0A6; -.
DR   EnsemblBacteria; AAK33788; AAK33788; SPy_0865.
DR   KEGG; spy:SPy_0865; -.
DR   KEGG; spz:M5005_Spy0672; -.
DR   PATRIC; fig|160490.10.peg.742; -.
DR   HOGENOM; CLU_048251_3_1_9; -.
DR   OMA; MALGFCA; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.1180.10; -; 1.
DR   InterPro; IPR003797; DegV.
DR   InterPro; IPR043168; DegV_C.
DR   Pfam; PF02645; DegV; 1.
DR   TIGRFAMs; TIGR00762; DegV; 1.
DR   PROSITE; PS51482; DEGV; 1.
PE   3: Inferred from homology;
KW   Lipid-binding; Reference proteome.
FT   CHAIN           1..282
FT                   /note="DegV domain-containing protein
FT                   SPy_0865/M5005_Spy0672"
FT                   /id="PRO_0000209800"
FT   DOMAIN          3..280
FT                   /note="DegV"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00815"
FT   BINDING         61
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
FT   BINDING         94
FT                   /ligand="hexadecanoate"
FT                   /ligand_id="ChEBI:CHEBI:7896"
FT                   /evidence="ECO:0000250|UniProtKB:Q9X1H9"
SQ   SEQUENCE   282 AA;  31338 MW;  B6CE599F0019DB75 CRC64;
     MKLAVITDST ATLPTDLKQD KAIFSLDIPV IIDDETYFEG RNLSIDDFYQ KMADSQNLPK
     TSQPSLSELD NLLGLLSSKG YTHVIGLFLA GGISGFWQNI QFLAEEHPEI EMAFPDSKIT
     SAPLGSMVKN VLDWSRQGMT FQAILNKLQE QIDGTTAFIM VDDLNHLVKG GRLSNGSALL
     GNLLSIKPIL RFDEEGKIVV YEKVRTEKKA MKRLVEILND LIADGQYNVF IIHSKAQDKA
     DYLKRLLQDS GYQYDIEEVH FGAVIATHLG EGAIAFGVTP RL