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CAS_ORYSJ
ID   CAS_ORYSJ               Reviewed;         759 AA.
AC   Q6Z2X6; A0A0P0VEQ1; Q9SPJ0;
DT   05-SEP-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Cycloartenol synthase;
DE            EC=5.4.99.8;
GN   OrderedLocusNames=Os02g0139700, LOC_Os02g04710; ORFNames=OJ1679_B08.9;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 3-759.
RA   Darr L.B., Godzina S.M., Matsuda S.P.T.;
RT   "A rice cDNA similar to cycloartenol synthase.";
RL   (er) Plant Gene Register PGR99-155(1999).
RN   [6]
RP   FUNCTION, AND CATALYTIC ACTIVITY.
RX   PubMed=21526825; DOI=10.1021/ol200777d;
RA   Ito R., Mori K., Hashimoto I., Nakano C., Sato T., Hoshino T.;
RT   "Triterpene cyclases from Oryza sativa L.: cycloartenol, parkeol and
RT   achilleol B synthases.";
RL   Org. Lett. 13:2678-2681(2011).
CC   -!- FUNCTION: Converts oxidosqualene ((3S)-2,3-epoxy-2,3-dihydrosqualene)
CC       to cycloartenol. {ECO:0000269|PubMed:21526825}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-2,3-epoxysqualene = cycloartenol; Xref=Rhea:RHEA:21308,
CC         ChEBI:CHEBI:15441, ChEBI:CHEBI:17030; EC=5.4.99.8;
CC         Evidence={ECO:0000269|PubMed:21526825};
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000305}.
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DR   EMBL; AP005294; BAD10254.1; -; Genomic_DNA.
DR   EMBL; AP008208; BAF07762.1; -; Genomic_DNA.
DR   EMBL; AP014958; BAS76910.1; -; Genomic_DNA.
DR   EMBL; AK121211; BAH00370.1; -; mRNA.
DR   EMBL; AF169966; AAF03375.1; -; mRNA.
DR   RefSeq; XP_015625472.1; XM_015769986.1.
DR   AlphaFoldDB; Q6Z2X6; -.
DR   SMR; Q6Z2X6; -.
DR   STRING; 4530.OS02T0139700-01; -.
DR   PaxDb; Q6Z2X6; -.
DR   PRIDE; Q6Z2X6; -.
DR   EnsemblPlants; Os02t0139700-01; Os02t0139700-01; Os02g0139700.
DR   GeneID; 4328256; -.
DR   Gramene; Os02t0139700-01; Os02t0139700-01; Os02g0139700.
DR   KEGG; osa:4328256; -.
DR   eggNOG; KOG0497; Eukaryota.
DR   HOGENOM; CLU_009074_2_0_1; -.
DR   InParanoid; Q6Z2X6; -.
DR   OMA; NTRYIDI; -.
DR   OrthoDB; 365003at2759; -.
DR   BioCyc; MetaCyc:MON-17968; -.
DR   BRENDA; 5.4.99.8; 4460.
DR   Proteomes; UP000000763; Chromosome 2.
DR   Proteomes; UP000059680; Chromosome 2.
DR   Genevisible; Q6Z2X6; OS.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016871; F:cycloartenol synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   PANTHER; PTHR11764; PTHR11764; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; SSF48239; 2.
DR   TIGRFAMs; TIGR01787; squalene_cyclas; 1.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   1: Evidence at protein level;
KW   Isomerase; Reference proteome; Repeat.
FT   CHAIN           1..759
FT                   /note="Cycloartenol synthase"
FT                   /id="PRO_0000418964"
FT   REPEAT          148..189
FT                   /note="PFTB 1"
FT   REPEAT          513..558
FT                   /note="PFTB 2"
FT   REPEAT          590..630
FT                   /note="PFTB 3"
FT   REPEAT          639..680
FT                   /note="PFTB 4"
FT   ACT_SITE        484
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250|UniProtKB:P48449"
SQ   SEQUENCE   759 AA;  85682 MW;  63AEAECA524D6F94 CRC64;
     MWRLRVAEGG GDPWLRTKNG HVGRQVWEFD PAAGDPDELA AVEAARRGFA ARRHELKHSS
     DLLMRMQFAK ANPLKLDIPA IKLEEHEAVT GEAVLSSLKR AIARYSTFQA HDGHWPGDYG
     GPMFLMPGLI ITLYVSGALN TALSSEHQKE IRRYLYNHQN EDGGWGLHIE GHSTMFGSAL
     TYVSLRLLGE GPDSGDGAME KGRKWILDHG GATYITSWGK FWLSVLGVFD WSGNNPVPPE
     IWLLPYFLPI HPGRMWCHCR MVYLPMCYIY GKRFVGPVTP IILELRKELY EVPYNEVDWD
     KARNLCAKED LYYPHPFVQD VLWATLHKFV EPAMLRWPGN KLREKALDTV MQHIHYEDEN
     TRYICIGPVN KVLNMLACWI EDPNSEAFKL HIPRVHDYLW IAEDGMKMQG YNGSQLWDTA
     FTVQAIVATG LIEEFGPTLK LAHGYIKKTQ VIDDCPGDLS QWYRHISKGA WPFSTADHGW
     PISDCTAEGL KAALLLSKIS PDIVGEAVEV NRLYDSVNCL MSYMNDNGGF ATYELTRSYA
     WLELINPAET FGDIVIDYPY VECTSAAIQA LTAFKKLYPG HRKSEIDNCI SKAASFIEGI
     QKSDGSWYGS WAVCFTYGTW FGVKGLVAAG RTFKNSPAIR KACDFLLSKE LPSGGWGESY
     LSSQDQVYTN LEGKRPHAVN TGWAMLALID AGQAERDPIP LHRAAKVLIN LQSEDGEFPQ
     QEIIGVFNKN CMISYSEYRN IFPIWALGEY RRRVLAADK
 
 
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