ID   Y876_MYCTU              Reviewed;         559 AA.
AC   P9WKR5; L0T6P7; Q10564;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Uncharacterized protein Rv0876c;
GN   OrderedLocusNames=Rv0876c; ORFNames=MTCY31.04c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: To M.leprae ML2143. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCP43624.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AL123456; CCP43624.1; ALT_INIT; Genomic_DNA.
DR   PIR; A70780; A70780.
DR   RefSeq; NP_215391.1; NC_000962.3.
DR   AlphaFoldDB; P9WKR5; -.
DR   STRING; 83332.Rv0876c; -.
DR   PaxDb; P9WKR5; -.
DR   GeneID; 885562; -.
DR   KEGG; mtu:Rv0876c; -.
DR   PATRIC; fig|83332.12.peg.978; -.
DR   TubercuList; Rv0876c; -.
DR   eggNOG; COG2814; Bacteria.
DR   OMA; KAYGVVR; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..559
FT                   /note="Uncharacterized protein Rv0876c"
FT                   /id="PRO_0000103719"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        259..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        283..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        358..378
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        428..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        490..510
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        515..535
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   559 AA;  59145 MW;  0811EB61C77C5616 CRC64;
     MSGRRGDHPG RMAPTPGRRT RNGSVNGHPG MANYPPDDAN YRRSRRPPPM PSANRYLPPL
     GEQPEPERSR VPPRTTRAGE RITVTRAAAM RSREMGSRMY LLVHRAATAD GADKSGLTAL
     TWPVMANFAV DSAMAVALAN TLFFAAASGE SKSRVALYLL ITIAPFAVIA PLIGPALDRL
     QHGRRVALAL SFGLRTALAV VLIMNYDGAT GSFPSWVLYP CALAMMVFSK SFSVLRSAVT
     PRVMPPTIDL VRVNSRLTVF GLLGGTIAGG AIAAGVEFVC THLFQLPGAL FVVVAITIAG
     ASLSMRIPRW VEVTSGEVPA TLSYHRDRGR LRRRWPEEVK NLGGTLRQPL GRNIITSLWG
     NCTIKVMVGF LFLYPAFVAK AHEANGWVQL GMLGLIGAAA AVGNFAGNFT SARLQLGRPA
     VLVVRCTVLV TVLAIAAAVA GSLAATAIAT LITAGSSAIA KASLDASLQH DLPEESRASG
     FGRSESTLQL AWVLGGAVGV LVYTELWVGF TAVSALLILG LAQTIVSFRG DSLIPGLGGN
     RPVMAEQETT RRGAAVAPQ