ID   Y8812_DICDI             Reviewed;         409 AA.
AC   Q55EN5;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Putative actin-fragmin kinase DDB_G0268812;
GN   ORFNames=DDB_G0268812;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA   Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT   "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT   model organism.";
RL   PLoS Genet. 2:E38-E38(2006).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. AFK Ser/Thr
CC       protein kinase family. {ECO:0000305}.
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DR   EMBL; AAFI02000004; EAL72995.1; -; Genomic_DNA.
DR   RefSeq; XP_646985.1; XM_641893.1.
DR   AlphaFoldDB; Q55EN5; -.
DR   SMR; Q55EN5; -.
DR   PaxDb; Q55EN5; -.
DR   EnsemblProtists; EAL72995; EAL72995; DDB_G0268812.
DR   GeneID; 8616676; -.
DR   KEGG; ddi:DDB_G0268812; -.
DR   dictyBase; DDB_G0268812; -.
DR   eggNOG; ENOG502RDNC; Eukaryota.
DR   HOGENOM; CLU_054301_0_0_1; -.
DR   InParanoid; Q55EN5; -.
DR   PhylomeDB; Q55EN5; -.
DR   PRO; PR:Q55EN5; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05124; AFK; 1.
DR   Gene3D; 1.10.1070.11; -; 1.
DR   InterPro; IPR015275; Actin-fragmin_kin_cat_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR037469; Put_AFK.
DR   PANTHER; PTHR38737; PTHR38737; 1.
DR   Pfam; PF09192; Act-Frag_cataly; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Kinase; Reference proteome; Transferase.
FT   CHAIN           1..409
FT                   /note="Putative actin-fragmin kinase DDB_G0268812"
FT                   /id="PRO_0000367581"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          5..46
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        16..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   409 AA;  47695 MW;  B02A6D92F17CDE7A CRC64;
     MKTFRDFKKK IKNNNNNKNN KNNNINNNNS NNNKNNKNNN NNNSNNIYTP SISIIDNYDT
     LCSTPQNLKS NLKKNLNINN QEFITSNILE IDWNTIIDIE IIDFGNSIVC LLVTLSSDNL
     HFNQILIKST PTIAQECYAS VLQNILKLPI LDLRLLEKNN EFLEMSSNLL DFSKDDQFLN
     DFIKSEFEKT FFLIMEFRQN GKKFNELNHK EYFSGYKGQE KFKQLGKIIA FDIFCNNFCK
     TNIAGDDSSI YFSNIICYET PNKNGWYFSL INSNISCLNN SLFTIGYRYH MNSLKLLLFS
     IFQNPSTESF QIRMMREHLL KKLNIKLPKS SAVYIQKGIA KGIKSIVNYI NYPLLENTKD
     KVKNIVSCDN YNIWKKGIDS IHCPFLLDVL NEIEIEISNR REKVYFVKI