位置:首页 > 蛋白库 > CAT3_STAAU
CAT3_STAAU
ID   CAT3_STAAU              Reviewed;         215 AA.
AC   P06135;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1988, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Chloramphenicol acetyltransferase;
DE            Short=CAT;
DE            EC=2.3.1.28;
GN   Name=cat;
OS   Staphylococcus aureus.
OG   Plasmid pUB112.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3865770; DOI=10.1002/j.1460-2075.1985.tb03929.x;
RA   Brueckner R., Matzura H.;
RT   "Regulation of the inducible chloramphenicol acetyltransferase gene of the
RT   Staphylococcus aureus plasmid pUB112.";
RL   EMBO J. 4:2295-2300(1985).
CC   -!- FUNCTION: This enzyme is an effector of chloramphenicol resistance in
CC       bacteria.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + chloramphenicol = chloramphenicol 3-acetate +
CC         CoA; Xref=Rhea:RHEA:18421, ChEBI:CHEBI:16730, ChEBI:CHEBI:17698,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.28;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10021};
CC   -!- SUBUNIT: Homotrimer.
CC   -!- INDUCTION: By subinhibitory concentrations of chloramphenicol.
CC   -!- SIMILARITY: Belongs to the chloramphenicol acetyltransferase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X02872; CAA26631.1; -; Genomic_DNA.
DR   RefSeq; WP_032488460.1; NZ_VRNK01000199.1.
DR   AlphaFoldDB; P06135; -.
DR   SMR; P06135; -.
DR   GO; GO:0008811; F:chloramphenicol O-acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; -; 1.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR018372; Chloramphenicol_AcTrfase_AS.
DR   InterPro; IPR001707; Cmp_AcTrfase.
DR   PANTHER; PTHR38474; PTHR38474; 1.
DR   Pfam; PF00302; CAT; 1.
DR   PIRSF; PIRSF000440; CAT; 1.
DR   SMART; SM01059; CAT; 1.
DR   PROSITE; PS00100; CAT; 1.
PE   2: Evidence at transcript level;
KW   Acyltransferase; Antibiotic resistance; Plasmid; Transferase.
FT   CHAIN           1..215
FT                   /note="Chloramphenicol acetyltransferase"
FT                   /id="PRO_0000165872"
FT   ACT_SITE        189
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10021"
SQ   SEQUENCE   215 AA;  25711 MW;  44D598FDEA06114A CRC64;
     MTFNIIKLEN WDRKEYFEHY FNQQTTYSIT KEIDITLFKD MIKKKGYEIY PSLIYAIMEV
     VNKNKVFRTG INSENKLGYW DKLNPLYTVF NKQTEKFTNI WTESDNNFTS FYNNYKNDLF
     EYKDKEEMFP KKPIPENTIP ISMIPWIDFS SFNLNIGNNS SFLLPIITIG KFYSENNKIY
     IPVALQLHHA VCDGYHASLF INEFQDIINK VDDWI
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024