Y8827_DICDI
ID Y8827_DICDI Reviewed; 1816 AA.
AC Q54XN7;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=Uncharacterized helicase DDB_G0278827;
DE EC=3.6.4.-;
GN ORFNames=DDB_G0278827;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the helicase family. SKI2 subfamily.
CC {ECO:0000305}.
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DR EMBL; AAFI02000024; EAL68015.1; -; Genomic_DNA.
DR RefSeq; XP_641993.1; XM_636901.1.
DR AlphaFoldDB; Q54XN7; -.
DR STRING; 44689.DDB0206223; -.
DR PaxDb; Q54XN7; -.
DR PRIDE; Q54XN7; -.
DR EnsemblProtists; EAL68015; EAL68015; DDB_G0278827.
DR GeneID; 8621725; -.
DR KEGG; ddi:DDB_G0278827; -.
DR dictyBase; DDB_G0278827; -.
DR eggNOG; KOG0949; Eukaryota.
DR HOGENOM; CLU_002305_0_0_1; -.
DR InParanoid; Q54XN7; -.
DR OMA; IFDEVHQ; -.
DR PhylomeDB; Q54XN7; -.
DR PRO; PR:Q54XN7; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus;
KW Reference proteome.
FT CHAIN 1..1816
FT /note="Uncharacterized helicase DDB_G0278827"
FT /id="PRO_0000367266"
FT DOMAIN 826..999
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 1198..1379
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT REGION 338..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1388..1487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 949..952
FT /note="DEAH box"
FT COMPBIAS 562..580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1398..1444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1457..1487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 839..846
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 1816 AA; 210540 MW; 89BDE4CF55CBFC57 CRC64;
MENIEKKLML GDLLFPTKTF NVLSDFGADE PFLIDGDSLI LYLFSTFNIS SHKIKDKQLL
STDKCQSILF FHYFESFIAN VLNRKTKFQI FFIDENQYFY KNNTLKLIRK ICIDYYINND
KKNVLNNSNV QFTLIKSKWW EDFSSIESYL LENMFSFMLV LFPAQESFEK YYRVDIQEVF
ILKTMKFLDY VVEFNSISFE GSCIETIIYG KGTMFQRGYP YFCNKEFFKQ IDSFYNNEFE
NFNSDKLSFK DQNQILFNQQ QSENRDNEIN LLISTMFNND ISNNLNRIYC IYLVLLESLS
IRDRGFILPT CYKIDENVLN FLDNASYKNL LYLQQVSDSS SSSSNNNNNN NNNNNNNNEN
INLDYLDFKL FYQILIQIQI KLPKDLNELN NIFGEEIIIK SKLIWNNVKK DFGYDIGEFD
NFELFSNFQD RNNNLNDIIQ EMERRTKEIN SIDNSIYLVE NDFIRSVAPQ AYEYLKPFQS
ENYPDAESTI NTRFIDNYHF HSTRTIEPDA FSIKLKETTF KTKKHKQRAE DKSVGSFKKY
ADSLNDPRNI LIINKLNPTK EELEKERIKK EKEDSKKSYK KQSSSSSSSS TTTTSTTTSS
TIKPKSEIGK LLESRLNQDK KRYESELDDC KSIKSFLKFL NNLDLLTSLP ELYLQYFDHL
INFLVKQKED LIEEKKRTIL LERKQQSKTK THIELSEYEE KEIETSLELG IKEKSQFYQM
IQKYLRSFIT EKSKILSTKL QIDFANRFYT ISKSLIGLSD LSNFINDHWK LKLPKLDESD
VGNQQLKNSI EFQLKHSPDT LIRNTGSVED SRVRHFKPDA WQVELLDIVD KRESALICAS
TSSGKTFISF YCFEQILKES NDGIVVFVCP TKALVNQMYA EVLGRYDKNY QAINHRPSNH
KMVGVFTRDF RLNIETCQIL ITVPQCLEIL FLSIMNTHFI QRCRYIIFDE VHQIASSVDG
AIWERLLVFN PAPFLALSAT LGNLTDFHNF LKKIDPNRKV SLIHYQSRFN DLKNFFLCQT
PAKDNKSFPT YTIEPLHPMA TLDQKKTGLS DISPDLKLIA GEAIQMYQVL KEKLGYEKVN
HLDPVKFFAN IPNKQFNLEK QHIEIYQAEL KQFYTNLPSM TEKQLVVKAL TSPKYNDSLK
FDWASEITNI VLELQKQDLL PALFFSFNRS LCSRLAQRVY NDITHRNTNP NIIEEKKQLD
LVIERFQKSL GRALADLEPN DPEKMELERL KAKRASLDYL KPQFGNLLSS DIDEKVKKDP
LAPALTQGIA AHHGGCDKNY LRNVEYLFRS KKIQVVFATS TLAVGVNAPA KSSVFLGDSP
YLNVLTSKQC AGRAGRRGFD NYGNVIFVGL PKQKINRLLN SRLSNIIGNS VVSPSLCLSL
VSRYDYSTNG SANKSNEENK VQVKENEKER EKEKEKEKEK EKEKETIADN WDDDDDKKEI
TVADNWDDDE EETAESTKTT PATTPTTTTT ENTPATTTTT KTPTTTSLKK LSSEDILDVQ
ILKKSTKSLL NNSFFLGNPL QVQFQFLFSI DYLYRETYLS KDCVPMDNFS GIVTHLSYLE
PFNFTFVSLL KGGVFDNLPT NQKDCDYFII HILSYLFCVQ NIPSIYVRSP SILILPPLPP
TVHKIIKNHN DRLLKTFSTY LYVYKKYLKS TNDFLPFSSN DLKDSQKTTT TTTTATTSTI
TNKWNENFEK LKPSTENFNT GDLLSGIFKV SNLKKLKNIL GSNTYFSTRI LPYCNVDGSP
VNSYLLDFYK HSQKKPLIED NKIKESDLWT LLKEFSLILK VIATALTRRN PDSPISLAFS
GVAKRYIQKF SDNFDH
