Y882_METJA
ID Y882_METJA Reviewed; 197 AA.
AC Q58292;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Probable S-adenosylmethionine-dependent methyltransferase MJ0882;
DE EC=2.1.1.-;
GN OrderedLocusNames=MJ0882;
OS Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS 10045 / NBRC 100440) (Methanococcus jannaschii).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanocaldococcaceae; Methanocaldococcus.
OX NCBI_TaxID=243232;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT jannaschii.";
RL Science 273:1058-1073(1996).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 4-197, AND S-ADENOSYLMETHIONINE
RP BINDING.
RX PubMed=12836702; DOI=10.1023/a:1021279113558;
RA Huang L., Hung L., Odell M., Yokota H., Kim R., Kim S.H.;
RT "Structure-based experimental confirmation of biochemical function to a
RT methyltransferase, MJ0882, from hyperthermophile Methanococcus
RT jannaschii.";
RL J. Struct. Funct. Genomics 2:121-127(2002).
CC -!- FUNCTION: Probable methyltransferase that uses S-adenosylmethionine as
CC the methyl donor. Binds neither NAD nor NADP in vitro.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000305}.
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DR EMBL; L77117; AAB98886.1; -; Genomic_DNA.
DR PIR; B64410; B64410.
DR RefSeq; WP_010870396.1; NC_000909.1.
DR PDB; 1DUS; X-ray; 1.80 A; A=4-197.
DR PDBsum; 1DUS; -.
DR AlphaFoldDB; Q58292; -.
DR SMR; Q58292; -.
DR STRING; 243232.MJ_0882; -.
DR EnsemblBacteria; AAB98886; AAB98886; MJ_0882.
DR GeneID; 1451771; -.
DR KEGG; mja:MJ_0882; -.
DR eggNOG; arCOG00110; Archaea.
DR HOGENOM; CLU_018398_7_2_2; -.
DR InParanoid; Q58292; -.
DR OMA; HMIDVNE; -.
DR OrthoDB; 72076at2157; -.
DR PhylomeDB; Q58292; -.
DR EvolutionaryTrace; Q58292; -.
DR Proteomes; UP000000805; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR007848; Small_mtfrase_dom.
DR Pfam; PF05175; MTS; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Methyltransferase; Reference proteome;
KW S-adenosyl-L-methionine; Transferase.
FT CHAIN 1..197
FT /note="Probable S-adenosylmethionine-dependent
FT methyltransferase MJ0882"
FT /id="PRO_0000157176"
FT BINDING 63..67
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000305"
FT BINDING 84
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000305"
FT BINDING 129..132
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 129
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000305"
FT STRAND 14..21
FT /evidence="ECO:0007829|PDB:1DUS"
FT STRAND 24..31
FT /evidence="ECO:0007829|PDB:1DUS"
FT TURN 35..38
FT /evidence="ECO:0007829|PDB:1DUS"
FT HELIX 42..50
FT /evidence="ECO:0007829|PDB:1DUS"
FT STRAND 58..62
FT /evidence="ECO:0007829|PDB:1DUS"
FT HELIX 68..73
FT /evidence="ECO:0007829|PDB:1DUS"
FT HELIX 74..76
FT /evidence="ECO:0007829|PDB:1DUS"
FT STRAND 77..85
FT /evidence="ECO:0007829|PDB:1DUS"
FT HELIX 87..99
FT /evidence="ECO:0007829|PDB:1DUS"
FT STRAND 107..111
FT /evidence="ECO:0007829|PDB:1DUS"
FT TURN 114..117
FT /evidence="ECO:0007829|PDB:1DUS"
FT STRAND 123..128
FT /evidence="ECO:0007829|PDB:1DUS"
FT HELIX 136..149
FT /evidence="ECO:0007829|PDB:1DUS"
FT STRAND 150..162
FT /evidence="ECO:0007829|PDB:1DUS"
FT HELIX 164..177
FT /evidence="ECO:0007829|PDB:1DUS"
FT STRAND 181..186
FT /evidence="ECO:0007829|PDB:1DUS"
FT STRAND 189..195
FT /evidence="ECO:0007829|PDB:1DUS"
SQ SEQUENCE 197 AA; 22244 MW; F4E108E500ABEB28 CRC64;
MHYFSEKPTT KSDVKIVEDI LRGKKLKFKT DSGVFSYGKV DKGTKILVEN VVVDKDDDIL
DLGCGYGVIG IALADEVKST TMADINRRAI KLAKENIKLN NLDNYDIRVV HSDLYENVKD
RKYNKIITNP PIRAGKEVLH RIIEEGKELL KDNGEIWVVI QTKQGAKSLA KYMKDVFGNV
ETVTIKGGYR VLKSKKL
