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CAT4_MORMO
ID   CAT4_MORMO              Reviewed;         210 AA.
AC   P50869;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Chloramphenicol acetyltransferase;
DE            EC=2.3.1.28;
GN   Name=cat;
OS   Morganella morganii (Proteus morganii).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Morganellaceae; Morganella.
OX   NCBI_TaxID=582;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=4H9; TRANSPOSON=Tn840;
RA   Kupzig S., Bennett P.M.;
RL   Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: This enzyme is an effector of chloramphenicol resistance in
CC       bacteria.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + chloramphenicol = chloramphenicol 3-acetate +
CC         CoA; Xref=Rhea:RHEA:18421, ChEBI:CHEBI:16730, ChEBI:CHEBI:17698,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.28;
CC   -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC       {ECO:0000305}.
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DR   EMBL; X82455; CAA57832.1; -; Genomic_DNA.
DR   PIR; S49577; S49577.
DR   RefSeq; WP_048608591.1; NG_047615.1.
DR   AlphaFoldDB; P50869; -.
DR   SMR; P50869; -.
DR   GO; GO:0008811; F:chloramphenicol O-acetyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   InterPro; IPR001451; Hexapep.
DR   InterPro; IPR018357; Hexapep_transf_CS.
DR   InterPro; IPR011004; Trimer_LpxA-like_sf.
DR   Pfam; PF00132; Hexapep; 1.
DR   SUPFAM; SSF51161; SSF51161; 1.
DR   PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Antibiotic resistance; Repeat; Transferase;
KW   Transposable element.
FT   CHAIN           1..210
FT                   /note="Chloramphenicol acetyltransferase"
FT                   /id="PRO_0000068660"
FT   ACT_SITE        79
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   210 AA;  23704 MW;  5115F8097A7BFE8E CRC64;
     MKNYFDSPFK GELLSEQVKN PNIKVGRYSY YSGYYHGHSF DECARYLHPD RDDVDKLIIG
     SFCSIGSGAS FIMAGNQGHR HDWASSFPFF YMQEEPAFSS ALDAFQRAGD TAIGNDVWIG
     SEAMIMPGIK IGDGAVIGSR SLVTKDVVPY AIIGGSPAKQ IKKRFSDEEI SLLMEMEWWN
     WPLDKIKTAM PLLCSSNIFG LHKYWREFVV
 
 
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