CAT4_MORMO
ID CAT4_MORMO Reviewed; 210 AA.
AC P50869;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Chloramphenicol acetyltransferase;
DE EC=2.3.1.28;
GN Name=cat;
OS Morganella morganii (Proteus morganii).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Morganella.
OX NCBI_TaxID=582;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=4H9; TRANSPOSON=Tn840;
RA Kupzig S., Bennett P.M.;
RL Submitted (NOV-1994) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This enzyme is an effector of chloramphenicol resistance in
CC bacteria.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + chloramphenicol = chloramphenicol 3-acetate +
CC CoA; Xref=Rhea:RHEA:18421, ChEBI:CHEBI:16730, ChEBI:CHEBI:17698,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.28;
CC -!- SIMILARITY: Belongs to the transferase hexapeptide repeat family.
CC {ECO:0000305}.
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DR EMBL; X82455; CAA57832.1; -; Genomic_DNA.
DR PIR; S49577; S49577.
DR RefSeq; WP_048608591.1; NG_047615.1.
DR AlphaFoldDB; P50869; -.
DR SMR; P50869; -.
DR GO; GO:0008811; F:chloramphenicol O-acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR InterPro; IPR001451; Hexapep.
DR InterPro; IPR018357; Hexapep_transf_CS.
DR InterPro; IPR011004; Trimer_LpxA-like_sf.
DR Pfam; PF00132; Hexapep; 1.
DR SUPFAM; SSF51161; SSF51161; 1.
DR PROSITE; PS00101; HEXAPEP_TRANSFERASES; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Antibiotic resistance; Repeat; Transferase;
KW Transposable element.
FT CHAIN 1..210
FT /note="Chloramphenicol acetyltransferase"
FT /id="PRO_0000068660"
FT ACT_SITE 79
FT /evidence="ECO:0000250"
SQ SEQUENCE 210 AA; 23704 MW; 5115F8097A7BFE8E CRC64;
MKNYFDSPFK GELLSEQVKN PNIKVGRYSY YSGYYHGHSF DECARYLHPD RDDVDKLIIG
SFCSIGSGAS FIMAGNQGHR HDWASSFPFF YMQEEPAFSS ALDAFQRAGD TAIGNDVWIG
SEAMIMPGIK IGDGAVIGSR SLVTKDVVPY AIIGGSPAKQ IKKRFSDEEI SLLMEMEWWN
WPLDKIKTAM PLLCSSNIFG LHKYWREFVV