ID   Y886_METJA              Reviewed;         620 AA.
AC   Q58296;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Putative molybdopterin biosynthesis protein MJ0886;
GN   OrderedLocusNames=MJ0886;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis.
CC   -!- SIMILARITY: Belongs to the MoeA family. {ECO:0000305}.
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DR   EMBL; L77117; AAB98890.1; -; Genomic_DNA.
DR   PIR; F64410; F64410.
DR   RefSeq; WP_010870400.1; NC_000909.1.
DR   AlphaFoldDB; Q58296; -.
DR   SMR; Q58296; -.
DR   STRING; 243232.MJ_0886; -.
DR   PRIDE; Q58296; -.
DR   EnsemblBacteria; AAB98890; AAB98890; MJ_0886.
DR   GeneID; 1451775; -.
DR   KEGG; mja:MJ_0886; -.
DR   eggNOG; arCOG00217; Archaea.
DR   HOGENOM; CLU_010186_3_0_2; -.
DR   InParanoid; Q58296; -.
DR   OMA; IEAKTHS; -.
DR   OrthoDB; 51611at2157; -.
DR   PhylomeDB; Q58296; -.
DR   UniPathway; UPA00344; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0061599; F:molybdopterin molybdotransferase activity; IBA:GO_Central.
DR   GO; GO:0006777; P:Mo-molybdopterin cofactor biosynthetic process; IBA:GO_Central.
DR   GO; GO:0018315; P:molybdenum incorporation into molybdenum-molybdopterin complex; IBA:GO_Central.
DR   GO; GO:0032324; P:molybdopterin cofactor biosynthetic process; IEA:InterPro.
DR   CDD; cd00887; MoeA; 1.
DR   Gene3D; 2.40.340.10; -; 1.
DR   Gene3D; 3.40.980.10; -; 1.
DR   InterPro; IPR036425; MoaB/Mog-like_dom_sf.
DR   InterPro; IPR001453; MoaB/Mog_dom.
DR   InterPro; IPR008284; MoCF_biosynth_CS.
DR   InterPro; IPR038987; MoeA-like.
DR   InterPro; IPR005111; MoeA_C_domain_IV.
DR   InterPro; IPR036688; MoeA_C_domain_IV_sf.
DR   InterPro; IPR005110; MoeA_linker/N.
DR   InterPro; IPR036135; MoeA_linker/N_sf.
DR   InterPro; IPR024370; PBP_domain.
DR   PANTHER; PTHR10192; PTHR10192; 1.
DR   Pfam; PF00994; MoCF_biosynth; 1.
DR   Pfam; PF03454; MoeA_C; 1.
DR   Pfam; PF03453; MoeA_N; 1.
DR   Pfam; PF12727; PBP_like; 1.
DR   SMART; SM00852; MoCF_biosynth; 1.
DR   SUPFAM; SSF53218; SSF53218; 1.
DR   SUPFAM; SSF63867; SSF63867; 1.
DR   SUPFAM; SSF63882; SSF63882; 1.
DR   TIGRFAMs; TIGR00177; molyb_syn; 1.
DR   PROSITE; PS01079; MOCF_BIOSYNTHESIS_2; 1.
PE   3: Inferred from homology;
KW   Molybdenum cofactor biosynthesis; Reference proteome.
FT   CHAIN           1..620
FT                   /note="Putative molybdopterin biosynthesis protein MJ0886"
FT                   /id="PRO_0000171005"
SQ   SEQUENCE   620 AA;  68897 MW;  9B94AAA7CA6DF0AB CRC64;
     MTRYLTLHSI EEAKSIINES LKKLKNEVEE VDLFNAIGRV LAEDVFSNID IPPYDRAKMD
     GYAVKAEDTY EADEDNPVEL KVIGSLKAGE IKDLEINNGE CVEIATGAII PKGANAVVMV
     EYTERDNDRV KIYRAVPPME NIQFTGSDIM AGELVLRKNT KLTPRDIGVL AAIGKSKVKV
     YKKLKFGIIS TGNEIISPNE QLEFGKIYDI NSYTLVSYIK TLGYDFEFFG IAKDDKEELK
     EKIKKALKCD IILLSGGTSA GVGDLTETAI KELGGKILVH GIKIKPGKPT IIGKIDNKLI
     VGLPGYPTSC LTIFDVLFGD EKNVVKAKFP VRYISAKGRV EYLPVILVKH KNGFSAYPIT
     KGSGAITSLS EADGYIIIDE NKEILENEDV EVHLFGDVKV GLNIIGSHCI GVDIILKEAK
     LLAKTINVGS LGGVLSIKRG EADIAGIHLL DEKTNTYNIP FLEKYKVKDA VLVRGYIREQ
     GFMFRKELGF KSIEEIIEHI YKLEFINRNK GSGTRILFDK FLKDYNINPK EIKGYNIEAK
     THSAVATAIA MKKADIGLGI RTVAEQYNLA FIPLANEHYD FLIRKERFND EDVQNFIKAL
     KTAKLPFKKP DNCGEIIWGG