ID   Y890_MYCTU              Reviewed;         882 AA.
AC   P9WMG1; L0T7T8; Q10550;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Putative HTH-type transcriptional regulator Rv0890c;
GN   OrderedLocusNames=Rv0890c; ORFNames=MTCY31.18c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   INDUCTION IN HUMAN MACROPHAGES.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=16483748; DOI=10.1016/j.resmic.2005.10.007;
RA   Cappelli G., Volpe E., Grassi M., Liseo B., Colizzi V., Mariani F.;
RT   "Profiling of Mycobacterium tuberculosis gene expression during human
RT   macrophage infection: upregulation of the alternative sigma factor G, a
RT   group of transcriptional regulators, and proteins with unknown function.";
RL   Res. Microbiol. 157:445-455(2006).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- INDUCTION: Up-regulated 17-fold 7 days after infection of human
CC       macrophages. {ECO:0000269|PubMed:16483748}.
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DR   EMBL; AL123456; CCP43638.1; -; Genomic_DNA.
DR   PIR; G70781; G70781.
DR   RefSeq; NP_215405.1; NC_000962.3.
DR   RefSeq; WP_010886092.1; NC_000962.3.
DR   AlphaFoldDB; P9WMG1; -.
DR   SMR; P9WMG1; -.
DR   STRING; 83332.Rv0890c; -.
DR   PaxDb; P9WMG1; -.
DR   DNASU; 885227; -.
DR   GeneID; 885227; -.
DR   KEGG; mtu:Rv0890c; -.
DR   PATRIC; fig|83332.12.peg.993; -.
DR   TubercuList; Rv0890c; -.
DR   eggNOG; COG2197; Bacteria.
DR   eggNOG; COG3903; Bacteria.
DR   OMA; RYHWIAG; -.
DR   PhylomeDB; P9WMG1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..882
FT                   /note="Putative HTH-type transcriptional regulator Rv0890c"
FT                   /id="PRO_0000184201"
FT   DOMAIN          814..879
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        838..857
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   882 AA;  94496 MW;  752D2B40F10BD425 CRC64;
     MRALLAQNRL VTLCGTGGVG KTRLAIQIAS ASELRDGLCF VDLAPITESG IVAATAARAV
     GLPDQPGRST MDSLRRFIGN RRMLMVLDNC EHLLDACAAL VVELLGACPE LTILATSREP
     IGMAGEITWR VPSMSITDEA VELFADRASR VQPGFTIANH NAAAVGEICR RLDGIPLAIE
     FAAARVRSMS PLEIADGLDD CFRLLAGGVR GAVQRQQTLR ASIDWSHALL TETEQILFRR
     LAPFVGGFDL AAVRAVAAGS DLDPFSVLDQ LTLLVDKSLV VADDCQGRTR YRLLETVRRY
     ALEKLGDSGE ADVHARHRDY YTALAASLNT PADNDHQRLV ARAETEIDNL RAAFAWSREN
     GHITEALQLA SSLQPIWFGR AHLREGLSWF NSILEDQRFH RLAVSTAVRA RALADKAMLS
     TWLATSPVGA TDIIAPAQQA LAMAREVGDP AALVRALTAC GCSSGYNAEA AAPYFAEATD
     LARAIDDKWT LCQILYWRGV GTCISGDPNA LRAAAEECRD LADTIGDRFV SRHCSLWLSL
     AQMWAGNLTE ALELSREITA EAEASNDVPT KVLGLYTQAQ VLAYCGASAA HAIAGACIAA
     ATELGGVYQG IGYAAMTYAA LAAGDVTAAL EASDAARPIL RAQPDQVTMH QVLMAQLALA
     GGDAIAARQF ANDAVDATNG WHRMVALTIR ARVATARGEP ELARDDAHAA LACGAELHIY
     QGMPDAMELL AGLAGEVGSH SEGVRLLGAA AALRQQTRQV RFKIWDAGYQ ASVTALREAM
     GDEDFDRAWA EGAALSTDEA IAYAQRGRGE RKRPARGWGS LTPTERDVVR LVSEGLSNKD
     IAKRLFVSPR TVQTHLTHVY AKLGLPSRVQ LVDEAARRGS PS