ID   Y891_MYCTU              Reviewed;         285 AA.
AC   P9WMV1; L0T6R0; Q10551;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 32.
DE   RecName: Full=Uncharacterized protein Rv0891c;
GN   OrderedLocusNames=Rv0891c; ORFNames=MTCY31.19c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000255|PROSITE-ProRule:PRU00099}.
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DR   EMBL; AL123456; CCP43639.1; -; Genomic_DNA.
DR   PIR; H70781; H70781.
DR   RefSeq; NP_215406.1; NC_000962.3.
DR   RefSeq; WP_010886093.1; NC_000962.3.
DR   AlphaFoldDB; P9WMV1; -.
DR   SMR; P9WMV1; -.
DR   STRING; 83332.Rv0891c; -.
DR   PaxDb; P9WMV1; -.
DR   DNASU; 885493; -.
DR   GeneID; 885493; -.
DR   KEGG; mtu:Rv0891c; -.
DR   TubercuList; Rv0891c; -.
DR   eggNOG; COG2114; Bacteria.
DR   OMA; HVGSARS; -.
DR   PhylomeDB; P9WMV1; -.
DR   BRENDA; 4.6.1.1; 3445.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; -; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; SSF55073; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..285
FT                   /note="Uncharacterized protein Rv0891c"
FT                   /id="PRO_0000074130"
FT   DOMAIN          92..199
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00099"
SQ   SEQUENCE   285 AA;  31232 MW;  6C0AA6E53E62A9B7 CRC64;
     MLFNAVHNSL PPNIDIDHAI LRGEDHPPTC AKCVARVRIS ALGSLDLRYH SLRCYAAPPD
     VGRCEFVPPR RRVLIANQGL DVSRLPPTGT VTLLLADVEE STHLWQMCPE DMATAIAHLD
     HTVSEAITNH GGVQPVKRYE GDSFVAAFTR ASDAAACALD LQRTSLAPIR LRIGLHTGEV
     QLRDELYVGP TINRTARLRD LAHGGQVVLS AATGDLVTGR LPADAWLVDL GRHPLRGLPR
     PEWVMQLCHP DIREKFPPLR TAKSSPTSIL PAQFTTFVGR RAQIS