ID   Y8928_DICDI             Reviewed;         551 AA.
AC   Q55F11;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=PA-phosphatase related-family protein DDB_G0268928;
GN   ORFNames=DDB_G0268928;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=17259634; DOI=10.1099/mic.0.2006/000562-0;
RA   Serafimidis I., Bloomfield G., Skelton J., Ivens A., Kay R.R.;
RT   "A new environmentally resistant cell type from Dictyostelium.";
RL   Microbiology 153:619-630(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PA-phosphatase related phosphoesterase
CC       family. {ECO:0000305}.
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DR   EMBL; AAFI02000004; EAL73053.1; -; Genomic_DNA.
DR   RefSeq; XP_646859.1; XM_641767.1.
DR   AlphaFoldDB; Q55F11; -.
DR   PaxDb; Q55F11; -.
DR   EnsemblProtists; EAL73053; EAL73053; DDB_G0268928.
DR   GeneID; 8616542; -.
DR   KEGG; ddi:DDB_G0268928; -.
DR   dictyBase; DDB_G0268928; -.
DR   eggNOG; ENOG502SU9G; Eukaryota.
DR   HOGENOM; CLU_494708_0_0_1; -.
DR   InParanoid; Q55F11; -.
DR   OMA; WISTYFI; -.
DR   PRO; PR:Q55F11; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0070916; C:inositol phosphoceramide synthase complex; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045140; F:inositol phosphoceramide synthase activity; IBA:GO_Central.
DR   GO; GO:0006673; P:inositol phosphoceramide metabolic process; IBA:GO_Central.
DR   GO; GO:0030148; P:sphingolipid biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR026841; Aur1/Ipt1.
DR   InterPro; IPR036938; P_Acid_Pase_2/haloperoxi_sf.
DR   Pfam; PF14378; PAP2_3; 1.
DR   SUPFAM; SSF48317; SSF48317; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..551
FT                   /note="PA-phosphatase related-family protein DDB_G0268928"
FT                   /id="PRO_0000367483"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        232..252
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        346..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        474..494
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        500..520
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          26..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          123..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..172
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   551 AA;  61360 MW;  EF8E28D17524A4B7 CRC64;
     MGVQQQSELP SQTSAKYFSL REDVSTESLS DIDSQTDINN TGNSGKDYSS PPRLSLWGWY
     TPSQYRGNSS GVTMKNLSAS EDSISLSSLD HQQQPMLMVD HSSNSDNEDG ATAKDFKIDI
     HLKGEDEDDG SGDTRVKYNT RNSGTLRNSS NKTQTTVLNN STTSSNNINN NNDKEINITT
     LGGSTNSTTK FLYSSVDQSN GSTIRYPYSP SYSDATFSIL SGVVILFSII YSLLVGPIQI
     MFAFLVSILV FISYICASFA ANNRIYLYSI TALAVGLGLT IPSFFAATGA VVLGTGRDKS
     TWDVELFKSD QVLMGWMWPK GQMAIFVDES TIIGPDSFIG KLSTEILQLS YISYYIWGYF
     MEIYILYNLW RCHLSKDPQQ QKMMPIWDQR LKMFICSWIS TYFIVFSINL IFPAVSPRVY
     IGKTLNLYNN TLEGFGFAGF VRSRIDNAAK GSFGSFPSGH IATSFAIGLS SYKILPAYGF
     VSTIAAILIA IATMYLRYHY FVDFLAALPV TIFCLLYGGF YTPSDFKNVF VNCFYSIKSI
     FQNILSKFNN K