ID   Y892_MYCTU              Reviewed;         495 AA.
AC   P9WNG1; L0T532; P64745; Q10532;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 39.
DE   RecName: Full=Uncharacterized monooxygenase Rv0892;
DE            EC=1.14.13.-;
GN   OrderedLocusNames=Rv0892; ORFNames=MTCY31.20;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the FAD-binding monooxygenase family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP43640.1; -; Genomic_DNA.
DR   PIR; A70782; A70782.
DR   RefSeq; NP_215407.1; NC_000962.3.
DR   RefSeq; WP_003404651.1; NZ_NVQJ01000001.1.
DR   AlphaFoldDB; P9WNG1; -.
DR   SMR; P9WNG1; -.
DR   STRING; 83332.Rv0892; -.
DR   PaxDb; P9WNG1; -.
DR   DNASU; 885225; -.
DR   GeneID; 45424855; -.
DR   GeneID; 885225; -.
DR   KEGG; mtu:Rv0892; -.
DR   TubercuList; Rv0892; -.
DR   eggNOG; COG2072; Bacteria.
DR   OMA; CGCDVAS; -.
DR   PhylomeDB; P9WNG1; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0004499; F:N,N-dimethylaniline monooxygenase activity; IEA:InterPro.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   Gene3D; 3.50.50.60; -; 2.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR020946; Flavin_mOase-like.
DR   Pfam; PF00743; FMO-like; 1.
DR   SUPFAM; SSF51905; SSF51905; 2.
PE   1: Evidence at protein level;
KW   FAD; Flavoprotein; Monooxygenase; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..495
FT                   /note="Uncharacterized monooxygenase Rv0892"
FT                   /id="PRO_0000186458"
FT   BINDING         16
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         36
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         45
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         56
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         62
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   BINDING         105
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   SITE            286
FT                   /note="Transition state stabilizer"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   495 AA;  55039 MW;  08CB55F48674DB44 CRC64;
     MTGRCPTVAV VGAGMSGMCV AITLLSAGIT DVCIYEKADD VGGTWRDNTY PGLTCDVPSR
     LYQYSFAKNP NWTQMFSRGG EIQDYLRGIA ERYGLRHRIR FGATVVSARF DDGRWVLRTD
     SGTESTVDFL ISATGVLHHP RIPPIAGLDD FRGTVFHSAR WDHTVPLLGR RIAVIGTGST
     GVQLVCGLAG VAGKVTMFQR TAQWVLPWPN PRYSKLARVF HRAFPCLGSL AYKAYSLSFE
     TFAVALSNPG LHRKLVGAVC RASLRRVRDP RLRRALTPDY EPMCKRLVMS GGFYRAIQRD
     DVELVTAGID HVEHRGIVTD DGVLHEVDVI VLATGFDSHA FFRPMQLTGR DGIRIDDVWQ
     DGPHAHQTVA IPGFPNFFMM LGPHSPVGNF PLTAVAESQA EHIVQWIKRW RHGEFDTMEP
     KSAATEAYNT VLRAAMPNTV WTTGCDSWYL NKDGIPEVWP FAPAKHRAML ANLHPEEYDL
     RRYAAVRATS RPQSA