ID   Y893_HAEIN              Reviewed;         187 AA.
AC   P44923;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator HI_0893;
GN   OrderedLocusNames=HI_0893;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
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DR   EMBL; L42023; AAC22553.1; -; Genomic_DNA.
DR   PIR; F64100; F64100.
DR   RefSeq; NP_439054.1; NC_000907.1.
DR   RefSeq; WP_005693244.1; NC_000907.1.
DR   PDB; 3QKX; X-ray; 2.35 A; A/B=1-187.
DR   PDBsum; 3QKX; -.
DR   AlphaFoldDB; P44923; -.
DR   SMR; P44923; -.
DR   STRING; 71421.HI_0893; -.
DR   DNASU; 949896; -.
DR   EnsemblBacteria; AAC22553; AAC22553; HI_0893.
DR   KEGG; hin:HI_0893; -.
DR   PATRIC; fig|71421.8.peg.935; -.
DR   eggNOG; COG1309; Bacteria.
DR   HOGENOM; CLU_069356_12_9_6; -.
DR   OMA; RYFENKD; -.
DR   PhylomeDB; P44923; -.
DR   BioCyc; HINF71421:G1GJ1-933-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001647; HTH_TetR.
DR   Pfam; PF00440; TetR_N; 1.
DR   PRINTS; PR00455; HTHTETR.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS01081; HTH_TETR_1; 1.
DR   PROSITE; PS50977; HTH_TETR_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Reference proteome; Repeat; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..187
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   HI_0893"
FT                   /id="PRO_0000070657"
FT   DOMAIN          6..66
FT                   /note="HTH tetR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   DNA_BIND        29..48
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00335"
FT   HELIX           5..22
FT                   /evidence="ECO:0007829|PDB:3QKX"
FT   HELIX           30..37
FT                   /evidence="ECO:0007829|PDB:3QKX"
FT   HELIX           41..47
FT                   /evidence="ECO:0007829|PDB:3QKX"
FT   STRAND          48..50
FT                   /evidence="ECO:0007829|PDB:3QKX"
FT   HELIX           51..71
FT                   /evidence="ECO:0007829|PDB:3QKX"
FT   HELIX           80..97
FT                   /evidence="ECO:0007829|PDB:3QKX"
FT   HELIX           99..108
FT                   /evidence="ECO:0007829|PDB:3QKX"
FT   TURN            112..120
FT                   /evidence="ECO:0007829|PDB:3QKX"
FT   HELIX           125..136
FT                   /evidence="ECO:0007829|PDB:3QKX"
FT   HELIX           144..150
FT                   /evidence="ECO:0007829|PDB:3QKX"
FT   HELIX           153..164
FT                   /evidence="ECO:0007829|PDB:3QKX"
FT   HELIX           171..183
FT                   /evidence="ECO:0007829|PDB:3QKX"
SQ   SEQUENCE   187 AA;  22022 MW;  53868EF738C024CD CRC64;
     MRQAKTDLAE QIFSATDRLM AREGLNQLSM LKLAKEANVA AGTIYLYFKN KDELLEQFAH
     RVFSMFMATL EKDFDETKPF FEQYRQMWKN IWYFLQENPT ILSNLKQYES LPNFKDICKN
     IKNCRWDLFC HQAQKAGLLA ELSEDILFLL SLKTAINLAS DAKFIDFDLK PEILESVIER
     SWRAIQK