Y8948_DICDI
ID Y8948_DICDI Reviewed; 263 AA.
AC Q55EX9;
DT 20-APR-2010, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Putative methyltransferase DDB_G0268948;
DE EC=2.1.1.-;
GN ORFNames=DDB_G0268948;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=16512674; DOI=10.1021/pr050350q;
RA Reinders Y., Schulz I., Graef R., Sickmann A.;
RT "Identification of novel centrosomal proteins in Dictyostelium discoideum
RT by comparative proteomic approaches.";
RL J. Proteome Res. 5:589-598(2006).
RN [3]
RP IDENTIFICATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=AX2;
RX PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA Soldati T.;
RT "Proteomics fingerprinting of phagosome maturation and evidence for the
RT role of a Galpha during uptake.";
RL Mol. Cell. Proteomics 5:2228-2243(2006).
RN [4]
RP INDUCTION [LARGE SCALE ANALYSIS].
RX PubMed=18590548; DOI=10.1186/1471-2180-8-109;
RA Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R.,
RA Ivens A., Martinez J.L., Escalante R.;
RT "Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common
RT and specific effects from PAO1 and PA14 strains.";
RL BMC Microbiol. 8:109-109(2008).
RN [5]
RP INDUCTION.
RX PubMed=18990192; DOI=10.1111/j.1365-2958.2008.06497.x;
RA Choi C.H., Park S.J., Jeong S.Y., Yim H.S., Kang S.O.;
RT "Methylglyoxal accumulation by glutathione depletion leads to cell cycle
RT arrest in Dictyostelium.";
RL Mol. Microbiol. 70:1293-1304(2008).
RN [6]
RP IDENTIFICATION [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=19482547; DOI=10.1016/j.ijmm.2009.03.006;
RA Shevchuk O., Batzilla C., Haegele S., Kusch H., Engelmann S., Hecker M.,
RA Haas A., Heuner K., Gloeckner G., Steinert M.;
RT "Proteomic analysis of Legionella-containing phagosomes isolated from
RT Dictyostelium.";
RL Int. J. Med. Microbiol. 299:489-508(2009).
CC -!- INDUCTION: Up-regulated by Pseudomonas aeruginosa, PAO1 strain and PA14
CC strain infection. Up-regulated in gcsA null cells devoid of
CC glutathione. {ECO:0000269|PubMed:18590548,
CC ECO:0000269|PubMed:18990192}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL73063.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AAFI02000004; EAL73063.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_646891.1; XM_641799.1.
DR AlphaFoldDB; Q55EX9; -.
DR SMR; Q55EX9; -.
DR IntAct; Q55EX9; 1.
DR STRING; 44689.DDB0233914; -.
DR PaxDb; Q55EX9; -.
DR EnsemblProtists; EAL73063; EAL73063; DDB_G0268948.
DR GeneID; 8616576; -.
DR KEGG; ddi:DDB_G0268948; -.
DR dictyBase; DDB_G0268948; -.
DR eggNOG; KOG3010; Eukaryota.
DR InParanoid; Q55EX9; -.
DR PhylomeDB; Q55EX9; -.
DR PRO; PR:Q55EX9; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR013216; Methyltransf_11.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR Pfam; PF08241; Methyltransf_11; 1.
DR SUPFAM; SSF53335; SSF53335; 1.
PE 1: Evidence at protein level;
KW Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW Transferase.
FT CHAIN 1..263
FT /note="Putative methyltransferase DDB_G0268948"
FT /id="PRO_0000393367"
SQ SEQUENCE 263 AA; 29985 MW; DF7D89BE5F47BEAC CRC64;
MTSPIPTPTK FDDKFGSISK SYKNFRPTYN DELYSIIDSH CDEKRDLAID IGAGSGQATV
RLAKYFKKVI GFEPSQGQIE NAEKTDNVEY RLSAAEKIDL PSGSVDLITV AQAAHWFNLP
VFYEESKRLL RENGSLIIWS YGLMKITNNN DAQVVHEKHY YETIGDQYWA PERKYIDDEY
VDIKPSFENT TRKTISLPKS MSINDMIGYY SSWSGYAAFI KAGNKDVLPE IKETLLKAYK
TTDGDSKLID VNFPVYMILS KKE
