ID   Y894_MYCTU              Reviewed;         393 AA.
AC   P9WKP9; L0T813; P64749; Q10553;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Uncharacterized protein Rv0894;
GN   OrderedLocusNames=Rv0894; ORFNames=MTCY31.22;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
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DR   EMBL; AL123456; CCP43642.1; -; Genomic_DNA.
DR   PIR; C70782; C70782.
DR   RefSeq; NP_215409.1; NC_000962.3.
DR   RefSeq; WP_003404660.1; NZ_NVQJ01000001.1.
DR   AlphaFoldDB; P9WKP9; -.
DR   SMR; P9WKP9; -.
DR   STRING; 83332.Rv0894; -.
DR   PaxDb; P9WKP9; -.
DR   DNASU; 885199; -.
DR   GeneID; 885199; -.
DR   KEGG; mtu:Rv0894; -.
DR   TubercuList; Rv0894; -.
DR   eggNOG; COG3903; Bacteria.
DR   OMA; ISGWTQE; -.
DR   PhylomeDB; P9WKP9; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   4: Predicted;
KW   ATP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..393
FT                   /note="Uncharacterized protein Rv0894"
FT                   /id="PRO_0000103735"
FT   BINDING         67..74
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   393 AA;  42873 MW;  5EF7BE41F4E51715 CRC64;
     MPSRATVQEF SDSYPFCHNG FRPIMMPKIV SVQHSTRRHL TSFVGRKAEL NDVRRLLSDK
     RLVTLTGPDG MGKSRLALQI GAQIAHEFTY GRWDCDLATV TDRDCVSISM LNALGLPVQP
     GLSAIDTLVG VINDARVLLV LDHCEHLLDA CAAIIDSLLR SCPRLTILTT STEAIGLAGE
     LTWRVPPLSL TNDAIELFVD RARRVRSDFA INADTAVTVG EICRRLDGVP LAIELAAART
     DTLSPVEILA GLNDRFRLVA GAAGNAVRPE QTLCATVQWS HALLSGPERA LLHRLAVFAG
     GFDLDGAQAV GANDEDFEGY QTLGRFAELV DKAFVVVENN RGRAGYRLLY SVRQYALEKL
     SESGEADAVL ARYRKHLKQP NQVVRAGSGG VRY