Y895_HAEIN
ID Y895_HAEIN Reviewed; 1032 AA.
AC Q57124; O05034;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Uncharacterized transporter HI_0895;
GN OrderedLocusNames=HI_0895;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Could be a drug efflux pump. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000305}.
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DR EMBL; L42023; AAC22555.1; -; Genomic_DNA.
DR PIR; H64100; H64100.
DR RefSeq; NP_439056.1; NC_000907.1.
DR AlphaFoldDB; Q57124; -.
DR SMR; Q57124; -.
DR STRING; 71421.HI_0895; -.
DR TCDB; 2.A.6.2.50; the resistance-nodulation-cell division (rnd) superfamily.
DR EnsemblBacteria; AAC22555; AAC22555; HI_0895.
DR KEGG; hin:HI_0895; -.
DR PATRIC; fig|71421.8.peg.937; -.
DR eggNOG; COG0841; Bacteria.
DR HOGENOM; CLU_002755_1_2_6; -.
DR OMA; REYPKMT; -.
DR PhylomeDB; Q57124; -.
DR BioCyc; HINF71421:G1GJ1-935-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IBA:GO_Central.
DR Gene3D; 3.30.2090.10; -; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR PANTHER; PTHR32063; PTHR32063; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82714; SSF82714; 2.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1032
FT /note="Uncharacterized transporter HI_0895"
FT /id="PRO_0000161856"
FT TOPO_DOM 1..17
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 18..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000250"
FT TOPO_DOM 37..337
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 338..357
FT /note="Helical; Name=2"
FT /evidence="ECO:0000250"
FT TOPO_DOM 358..363
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 364..383
FT /note="Helical; Name=3"
FT /evidence="ECO:0000250"
FT TOPO_DOM 384..389
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 390..411
FT /note="Helical; Name=4"
FT /evidence="ECO:0000250"
FT TOPO_DOM 412..438
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 439..457
FT /note="Helical; Name=5"
FT /evidence="ECO:0000250"
FT TOPO_DOM 458..470
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 471..493
FT /note="Helical; Name=6"
FT /evidence="ECO:0000250"
FT TOPO_DOM 494..529
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 530..548
FT /note="Helical; Name=7"
FT /evidence="ECO:0000250"
FT TOPO_DOM 549..852
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 853..872
FT /note="Helical; Name=8"
FT /evidence="ECO:0000250"
FT TOPO_DOM 873..878
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 879..898
FT /note="Helical; Name=9"
FT /evidence="ECO:0000250"
FT TOPO_DOM 899..910
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 911..932
FT /note="Helical; Name=10"
FT /evidence="ECO:0000250"
FT TOPO_DOM 933..960
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 961..979
FT /note="Helical; Name=11"
FT /evidence="ECO:0000250"
FT TOPO_DOM 980..992
FT /note="Periplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 993..1015
FT /note="Helical; Name=12"
FT /evidence="ECO:0000250"
FT TOPO_DOM 1016..1032
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1032 AA; 111634 MW; C06658844C8F3C90 CRC64;
MYEEIRMKFT DIFIRRPVLA VSISLLMIIL GLQAISKLAV REYPKMTTTV ITVSTAYPGA
DANLIQAFVT SKLEESIAQA DNIDYMSSTS APSSSTITIK MKLNTDPAGA LADVLAKVNA
VKSALPNGIE DPSVSSSSGG SGIMYISFRS KKLDSSQVTD YINRVVKPQF FTIEGVAEVQ
VFGAAEYALR IWLDPQKMAA QNLSVPTVMS ALSANNVQTA AGNDNGYYVS YRNKVETTTK
SVEQLSNLII SSNGDDLVRL RDIATVELNK ENDNSRATAN GAESVVLAIN PTSTANPLTV
AEKIRPLYES IKTQLPDSME SDILYDRTIA INSSIHEVIK TIGEATLIVL VVILMFIGSF
RAILIPILAI PISLIGVLML LQSFNFSINL MTLLALILAI GLVVDDAIVV LENIDRHIKA
GETPFRAAII GTREIAVPVI SMTIALIAVY SPMALMGGIT GTLFKEFALT LAGAVFISGV
VALTLSPMMS SKLLKSNAKP TWMEERVEHT LGKVNRVYEY MLDLVMLNRK SMLAFAVVIF
STLPFLFNSL SSELTPNEDK GAFIAIGNAP SSVNVDYIQN AMQPYMKNVM ETPEVSFGMS
IAGAPTSNSS LNIITLKDWK ERSRKQSAIM NEINEKAKSI PEVSVSAFNI PEIDTGEQGP
PVSIVLKTAQ DYKSLANTAE KFLSAMKASG KFIYTNLDLT YDTAQMTISV DKEKAGTYGI
TMQQISNTLG SFLSGATVTR VDVDGRAYKV ISQVKRDDRL SPESFQNYYL TASNGQSVPL
SSVISMKLET QPTSLPRFSQ LNSAEISAVP MPGISSGDAI AWLQQQATDN LPQGYTFDFK
SEARQLVQEG NALAVTFALA VIIIFLVLAI QFESIRDPMV IMISVPLAVS GALVSLNILS
FFSIAGTTLN IYSQVGLITL VGLITKHGIL MCEVAKEEQL NHGKTRIEAI THAAKVRLRP
ILMTTAAMVA GLIPLLYATG AGAVSRFSIG IVIVAGLSIG TIFTLFVLPV VYSYVATEHK
PLPVFDENKT TH
