ID   Y8969_DICDI             Reviewed;         452 AA.
AC   Q54H55;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=FAD-linked oxidoreductase DDB_G0289697;
DE            EC=1.-.-.-;
GN   ORFNames=DDB_G0289697;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   INDUCTION [LARGE SCALE ANALYSIS].
RX   PubMed=18590548; DOI=10.1186/1471-2180-8-109;
RA   Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R.,
RA   Ivens A., Martinez J.L., Escalante R.;
RT   "Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common
RT   and specific effects from PAO1 and PA14 strains.";
RL   BMC Microbiol. 8:109-109(2008).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- INDUCTION: Down-regulated by Pseudomonas aeruginosa, PAO1 strain and
CC       PA14 strain infection. {ECO:0000269|PubMed:18590548}.
CC   -!- SIMILARITY: Belongs to the oxygen-dependent FAD-linked oxidoreductase
CC       family. {ECO:0000305}.
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DR   EMBL; AAFI02000148; EAL62560.1; -; Genomic_DNA.
DR   RefSeq; XP_636063.1; XM_630971.1.
DR   AlphaFoldDB; Q54H55; -.
DR   SMR; Q54H55; -.
DR   PaxDb; Q54H55; -.
DR   EnsemblProtists; EAL62560; EAL62560; DDB_G0289697.
DR   GeneID; 8627273; -.
DR   KEGG; ddi:DDB_G0289697; -.
DR   dictyBase; DDB_G0289697; -.
DR   eggNOG; ENOG502S2FH; Eukaryota.
DR   HOGENOM; CLU_018354_10_0_1; -.
DR   InParanoid; Q54H55; -.
DR   OMA; FPQRSSH; -.
DR   PhylomeDB; Q54H55; -.
DR   PRO; PR:Q54H55; -.
DR   Proteomes; UP000002195; Chromosome 5.
DR   GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.43.10; -; 1.
DR   Gene3D; 3.30.465.10; -; 1.
DR   InterPro; IPR012951; BBE.
DR   InterPro; IPR016166; FAD-bd_PCMH.
DR   InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR   InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR   InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR   InterPro; IPR006094; Oxid_FAD_bind_N.
DR   Pfam; PF08031; BBE; 1.
DR   Pfam; PF01565; FAD_binding_4; 1.
DR   SUPFAM; SSF56176; SSF56176; 1.
DR   PROSITE; PS51387; FAD_PCMH; 1.
PE   2: Evidence at transcript level;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT   CHAIN           1..452
FT                   /note="FAD-linked oxidoreductase DDB_G0289697"
FT                   /id="PRO_0000388257"
FT   DOMAIN          44..212
FT                   /note="FAD-binding PCMH-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00718"
FT   MOD_RES         81
FT                   /note="Pros-8alpha-FAD histidine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   452 AA;  49844 MW;  BFDD756A9B62BF41 CRC64;
     MESNQKCGAT QIVNEFCESI EGIVFRKGSE EYKQNVNKRW NIDVVNTPLL IVYPKNIQDV
     VKAVNFSREC QLDFAVIAGA HGFKSTCDNG LLLNISSMKN IKVDEASKTV VVETGCTLGD
     LDKETSKFGL GIPSGHVSHT GLGGLTLGGG IGHLSRSLGL TSDNLIGCTL VNYKGEIEKV
     TDQSNKELIY AIRGAGSNFG VITDFTFKLH PVKDVYLGTF VYPHATSKEP LTLLGEYASS
     KDVPNELSCA ISITPEGVVV MAIYNGTEEQ GKPYIEKIAS FGVPVVSKIS MIPYVQLQCL
     IDNKVPHGLK YYQRGPFIKE ALNADMIEII LDAYNKHPTK SCAILLTHLG GKVREPVEDD
     FSSFAHRNSE YQIIFASIIP SDQDKPSIKQ WTADVHTKLM PYCFGDYSNT TDGTQPIEII
     YGKHTNKLIQ LKTKYDPLNF FKNNTNIKPI QN