ID   Y901_CHLAA              Reviewed;         316 AA.
AC   Q45826; A9WH39;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Uncharacterized RNA pseudouridine synthase Caur_0901;
DE            EC=5.4.99.-;
DE   AltName: Full=RNA pseudouridylate synthase;
DE   AltName: Full=RNA-uridine isomerase;
GN   OrderedLocusNames=Caur_0901;
OS   Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl).
OC   Bacteria; Chloroflexi; Chloroflexia; Chloroflexales; Chloroflexineae;
OC   Chloroflexaceae; Chloroflexus.
OX   NCBI_TaxID=324602;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29366 / DSM 635 / J-10-fl;
RX   PubMed=21714912; DOI=10.1186/1471-2164-12-334;
RA   Tang K.H., Barry K., Chertkov O., Dalin E., Han C.S., Hauser L.J.,
RA   Honchak B.M., Karbach L.E., Land M.L., Lapidus A., Larimer F.W.,
RA   Mikhailova N., Pitluck S., Pierson B.K., Blankenship R.E.;
RT   "Complete genome sequence of the filamentous anoxygenic phototrophic
RT   bacterium Chloroflexus aurantiacus.";
RL   BMC Genomics 12:334-334(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 64-316.
RX   PubMed=8661927; DOI=10.1007/s002030050337;
RA   Synstad B., Emmerhoff O., Sirevag R.;
RT   "Malate dehydrogenase from the green gliding bacterium Chloroflexus
RT   aurantiacus is phylogenetically related to lactic dehydrogenases.";
RL   Arch. Microbiol. 165:346-353(1996).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a pseudouridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; CP000909; ABY34134.1; -; Genomic_DNA.
DR   EMBL; X89038; CAA61435.1; -; Genomic_DNA.
DR   RefSeq; WP_012256790.1; NC_010175.1.
DR   RefSeq; YP_001634523.1; NC_010175.1.
DR   AlphaFoldDB; Q45826; -.
DR   SMR; Q45826; -.
DR   STRING; 324602.Caur_0901; -.
DR   EnsemblBacteria; ABY34134; ABY34134; Caur_0901.
DR   KEGG; cau:Caur_0901; -.
DR   PATRIC; fig|324602.8.peg.1032; -.
DR   eggNOG; COG0564; Bacteria.
DR   HOGENOM; CLU_016902_4_4_0; -.
DR   InParanoid; Q45826; -.
DR   Proteomes; UP000002008; Chromosome.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0120159; F:rRNA pseudouridine synthase activity; IEA:UniProt.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IBA:GO_Central.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM00363; S4; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome; RNA-binding.
FT   CHAIN           1..316
FT                   /note="Uncharacterized RNA pseudouridine synthase
FT                   Caur_0901"
FT                   /id="PRO_0000162731"
FT   DOMAIN          26..98
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT   ACT_SITE        148
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   316 AA;  35298 MW;  2D0C26B26FDA43C4 CRC64;
     MSGEGEIELL EAEERVVVVP PTQTAERIDR FLAGAMPDLS RAQVQRLIEQ GFVLYDGRSP
     RASQPVRPGA VIQLTIPPPI PTELVAEPIP LDVVYEDADI AVINKPAGMV VHPAPGHPRG
     TLVNALLARY PDLAIGGELR PGIVHRLDRD TSGLLVIARH DQAMRSLVDQ QQARRMRKIY
     QALVIGRPPE TGTIDAPIGR DPRDRLRMAV VPDGRPARTH YRLLDTFGDY SLLEVQLETG
     RTHQIRVHLR HLGYPIVGDP VYGPRRSHLH LSRQFLHAAY LGLVHPRSGR WQEFTAPLPA
     DLQIVLRQLQ DRASYH