ID   Y901_MYCTA              Reviewed;         325 AA.
AC   A5U0T2;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MRA_0901;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MRA_0901;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; CP000611; ABQ72632.1; -; Genomic_DNA.
DR   RefSeq; WP_003404654.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U0T2; -.
DR   SMR; A5U0T2; -.
DR   STRING; 419947.MRA_0901; -.
DR   EnsemblBacteria; ABQ72632; ABQ72632; MRA_0901.
DR   KEGG; mra:MRA_0901; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; NWDINTS; -.
DR   OrthoDB; 847145at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..325
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MRA_0901"
FT                   /id="PRO_0000361234"
FT   BINDING         126
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         155..156
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   325 AA;  36073 MW;  6280F61020906EDE CRC64;
     MRTEDDSWDV TTSVGSTGLL VAAARALETQ KADPLAIDPY AEVFCRAAGG EWADVLDGKL
     PDHYLTTGDF GEHFVNFQGA RTRYFDEYFS RATAAGMKQV VILAAGLDSR AFRLQWPIGT
     TIFELDRPQV LDFKNAVLAD YHIRPRAQRR SVAVDLRDEW QIALCNNGFD ANRPSAWIAE
     GLLVYLSAEA QQRLFIGIDT LASPGSHVAV EEATPLDPCE FAAKLERERA ANAQGDPRRF
     FQMVYNERWA RATEWFDERG WRATATPLAE YLRRVGRAVP EADTEAAPMV TAITFVSAVR
     TGLVADPART SPSSTSIGFK RFEAD