Y9086_DICDI
ID Y9086_DICDI Reviewed; 937 AA.
AC Q55EQ3;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 25-MAY-2022, entry version 71.
DE RecName: Full=Uncharacterized abhydrolase domain-containing protein DDB_G0269086;
DE EC=3.-.-.-;
GN ORFNames=DDB_G0269086;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP PROTEIN SEQUENCE OF 2-19; 51-64 AND 171-187, CLEAVAGE OF INITIATOR
RP METHIONINE, ACETYLATION AT THR-2, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=AX2;
RA Bienvenut W.V., Ura S., Insall R.H.;
RL Submitted (JUL-2009) to UniProtKB.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR EMBL; AAFI02000004; EAL73132.2; -; Genomic_DNA.
DR RefSeq; XP_646967.2; XM_641875.2.
DR AlphaFoldDB; Q55EQ3; -.
DR SMR; Q55EQ3; -.
DR STRING; 44689.DDB0252556; -.
DR ESTHER; dicdi-y9086; Monoglyceridelipase_lysophospholip.
DR PaxDb; Q55EQ3; -.
DR PRIDE; Q55EQ3; -.
DR EnsemblProtists; EAL73132; EAL73132; DDB_G0269086.
DR GeneID; 8616659; -.
DR KEGG; ddi:DDB_G0269086; -.
DR dictyBase; DDB_G0269086; -.
DR eggNOG; KOG1455; Eukaryota.
DR HOGENOM; CLU_312958_0_0_1; -.
DR InParanoid; Q55EQ3; -.
DR OMA; FENIAHA; -.
DR Reactome; R-DDI-1482883; Acyl chain remodeling of DAG and TAG.
DR Reactome; R-DDI-426048; Arachidonate production from DAG.
DR PRO; PR:Q55EQ3; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0016298; F:lipase activity; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR022742; Hydrolase_4.
DR Pfam; PF12146; Hydrolase_4; 1.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Acetylation; Coiled coil; Direct protein sequencing; Hydrolase;
KW Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|Ref.2"
FT CHAIN 2..937
FT /note="Uncharacterized abhydrolase domain-containing
FT protein DDB_G0269086"
FT /id="PRO_0000388372"
FT REGION 281..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 345..802
FT /evidence="ECO:0000255"
FT COMPBIAS 281..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..399
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..886
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 292
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT MOD_RES 2
FT /note="N-acetylthreonine"
FT /evidence="ECO:0000269|Ref.2"
SQ SEQUENCE 937 AA; 103186 MW; 61DC4483C3C8A27A CRC64;
MTSSVSNLLT SDKETLSLRT WTPKVKPIAT VTMIHGLGEH SGRYEHVFSR FAEQGIKVNA
FDQRGHGISS GVRGHSPSLE QSLKDIQLIA STAETDVPHF IYGHSFGGCL ALHYNLKKKD
HHPAGCIVTS PLIKPAIKVS GVKLSMGNLL GGLMPSWTIS NSIDPTLISK DSAVVNEYKQ
DKLVHNKISL GMAKWMLQRS EQLIDLAPQF DTPLLLVHAN DDKITCPKAS QQFYDRVPST
VDKTLKLWEN MYHEVHNEFA KEEFVTYILE WIKERIENAK NESPSSNINT TTTSTTTTTT
TTTSSPVVEE SKPVVEESKP VVEESKPVVE ESKPVVEESK PEPVVDDSKE KEEKERLEKE
EAAAKLEKER LEKEEAERVA KEAEEKRIKD EKEAQENLEK QQQEAAAAAQ AEKERLEKEE
ADKLEKERLE AEAAAAAQAE KERLEAEAAA AAQAEKERLE AEAAAAVQAE KERLEKEEAD
RLEKEKLEAE AAAATQAEKE RLEAEAAAAA QAEKERLEKE ETERLEKEKL EAEAAAAAQA
EKEKLEAEAA AAAQAEKERL EAEAAAAAQA EKERLEAEAA AAAQAEKERL EAEAAAAAQA
EKEEAERLEK EKLEAEAAAA QAEKERLEAE AAAAAQAEKE RLEAEAAAAA QAEKEKLEAE
AEAAAQAEKE RLEKEEAERL EKEKLEAEAA AAQAEKERLE AEAAAAAQAE KEKLEAEAAA
AQAEKERLEA EAAAAAQAEK ERLEKEETER LEKERLEAEA AAAQAEKERL EAEAAAAAQA
EKERLEAEAA AEKAAEETKV EEPVQEETKV EEPVQEEIKV EEPVQEETKV EEPVQEETKV
EEPVQEETKV EEPVQEETKV EEPVQEETKV EESTTEQAKP TETENKEETE EGEEVDEASN
TTTEQTTTNA NQPKKPNNNN NNNKGKGKKG KGKGGRK
