Y9099_DICDI
ID Y9099_DICDI Reviewed; 2242 AA.
AC Q54XA2;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=DEP domain-containing protein DDB_G0279099;
GN ORFNames=DDB_G0279099;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SIMILARITY: In the N-terminal section; belongs to the IML1 family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000027; EAL67888.1; -; Genomic_DNA.
DR RefSeq; XP_641865.1; XM_636773.1.
DR AlphaFoldDB; Q54XA2; -.
DR SMR; Q54XA2; -.
DR STRING; 44689.DDB0305021; -.
DR PaxDb; Q54XA2; -.
DR PRIDE; Q54XA2; -.
DR EnsemblProtists; EAL67888; EAL67888; DDB_G0279099.
DR GeneID; 8621871; -.
DR KEGG; ddi:DDB_G0279099; -.
DR dictyBase; DDB_G0279099; -.
DR eggNOG; KOG3572; Eukaryota.
DR HOGENOM; CLU_230757_0_0_1; -.
DR InParanoid; Q54XA2; -.
DR OMA; PYWLAIS; -.
DR Reactome; R-DDI-9639288; Amino acids regulate mTORC1.
DR PRO; PR:Q54XA2; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:1990130; C:GATOR1 complex; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR045838; DEPDC5_CTD.
DR InterPro; IPR027244; IML1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR13179; PTHR13179; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF19418; DEPDC5_CTD; 1.
DR Pfam; PF12257; IML1; 1.
DR SMART; SM00049; DEP; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR PROSITE; PS50186; DEP; 1.
PE 3: Inferred from homology;
KW Coiled coil; Reference proteome.
FT CHAIN 1..2242
FT /note="DEP domain-containing protein DDB_G0279099"
FT /id="PRO_0000388258"
FT DOMAIN 1556..1629
FT /note="DEP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00066"
FT REGION 388..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..965
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1287..1336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1384..1414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1446..1471
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1502..1521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1645..1763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1803..1910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2122..2145
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2165..2218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 392..440
FT /evidence="ECO:0000255"
FT COILED 1066..1101
FT /evidence="ECO:0000255"
FT COILED 1791..1821
FT /evidence="ECO:0000255"
FT COMPBIAS 578..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1108..1194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1384..1411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1807..1910
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2122..2140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2167..2218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2242 AA; 249308 MW; 3CB63788C3A543C3 CRC64;
MNNNNKKGVY ILWVHDQQFS KEELVVNPEY FPKLKIMDVL KIYSPSNPSK RLCLRVKQLS
PLKTKLQISI SKYVAGVFDF ALRKEVVVNI IPEKQAIIDF VELSFKDQYI GRSDMWRLKL
NLQNECVYVL KKLAFAQIRA QVEEMVSNGQ KVSSGLIDDS TKFVFRSRSA KFVLFIQMSK
EMWDYSPDGE LYFEKAVNGF LKNLFQRWKS LSVNHTITII LFSRTFHEND DILDEIPNIP
RNPQGKLYQD FYKVVVNEET RPDWSSIIVN LKREFNDYHT SVNWDIYGRN SALGKNSTAS
QGNFLEAINL GMSYFDKHYI DRDFTRTGQM IVVISAGTGI FEVDPDINLI TKQRMIDNGI
GCDLICLNNH PLHVVPLFKF TISNQNKSQN TIQNNNNNNN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN SNNNKNNQNN GKAISNIGRN NNNSNSGSSG NSNNSSGGQL YNFPYWLAIS
FYDENNTTTT TTDVTTNDKR NGLFVPQFKI PEKVNSFYYE DDEKPVYDFY IPKDPRNLPA
FATPKINHKY TSNSLGVNSY EDTIFNMPNG GGILDDSNAL GGNNNNNYNN NNGNGNGHNH
NNHNNNNNNN NNNDHGGHSD TEPSDFSDTE DNSSTTPNSQ YSRVAIGLND KKRATFQIGG
TRSSSSFENQ RTIINSTTSN NNNNNSNNVV NKRYTSTQHQ PILRNGGTIN NNNNNQQNHP
ISPSNSFDQK TIPYHNQLLS TIPPQLFGKK KKEINPFTYD STPFHLTSNR RRWSHLWFSP
NTYIFGKTNT NPNPFLPNWK SLCEPASLPI TTDYFPSTKD LKAKYREYVH NLTLPDDNEY
TNSFEALLKE LISQRLAQGY QLIMITNSEI DPTTTTTTGG TTTPATTTPA TTTPATTATS
TTPTTIITPT TNPSTATSAI ATPSMATPSS STTTTTTTAN LSTSPPNSSN TVPNSGGSGK
GTKKSYQLSL GHDFHSITYD PSNLSIQVKR YQRYNGRNSS GSKKLRYHYF LNTIHLQGFL
HNSIELQHTA SSEYPWNSLD NLICGQLAMS GFGPRIKYWR VLYAIIPTVE NNQHQQQLQL
EQQEKEKEKA RLAALEKKKP FPREDSFSTL ILPTNSSSSS SSSSSLPSTV STTNTNTNNN
NNNNNNNNNN NINTTVPTNV PTTTTTDDST VKNTSTTTAT TATEDHGLNT AFNSSSIPIP
SKLASPLQSP NLSPKASSVS TSMAALSSST LVSSNANTTT TNNPVLTTTT TTTTTTAVLN
SNGTPLVNSN SSSNSNFAQN SISMLNGSQQ QQQLIGSQSA PTSPLTPHKN INTNNNNNNN
TTTNTTNNNN SVMNGSAGII NSSSGLNGIK SPPLPILPSS NSLLSSNVSP SNNITPLNSI
TNSSELLPSS SGASSSSSNT LSSSNSGENN ALPEHTEEER LIAFNKFKEF INSQINRNQL
AANSNAQSSL LNSSTNNANS NNSSNSTNTS GTVIQQKLDI KTILFSSIET FDPSTIVSNE
KSNNNTYTNN NNNNNSINSL NYNSVPSQEQ IDLFKEKLYS SNLSGIFYRL NMPYPIGIKM
TERKYGIRRT SYKKCFIGAE CIDWMLQNIE ITKREEALII CQKMMDQKLI KQVEKSTFVD
GQFYYRLKED DLFISSPIIK TINNTNNNFN NNNTNSNNNQ QQQQQQQSIP SVTSSAVNSP
NKDSNTPDHS PISSPKQIGN KLSSSSNNTP STFLNSSTNN TNQSTNTTSS SSSTTNINTT
LNTNNTLSSS TPPITSIQSS MSNSTKSVVP ISSLSSLINN PSLRQSNTDY LTNKEKDKEK
EIDEANGDNN NNNNNNNNNN NNNNNNNNNN NNNNNSSNNG ENDSSSNSGQ GSLNSTLSSI
PPATTPNTNP LHFSGGISYG SSVQNSNQHQ QQQPQQPQQQ QQQQQQQQQQ PNNLIDYYEN
PNKISEAKIE MDLSKTDRFE WILMKYDKTF CPTRYFHVEF NWIVSTGCVV DDFINSCVRK
AKQFGLTLIQ IPMEKNYSPF SLPTHVHLDQ QLMSPQVLKH IFTKFGLIPD TIRKRASSLV
TRQDLYIFND SDVQYSEYVH RTGLLFVRVV EDGFLCYINN APSNRPFLPA ATMCLESFQN
LCNQLNNSLS FIGNGSLNSN NNYNNNNNNN NNNNGGGNGN PNLLKPIDRQ EANFLSLLAL
GYKQNSDTEE KNNESDSDNN HNQDTCDNSD NDTDHLSESH EGSHKNESDK EGRDKNEMWE
SQSEVVYYSV MSRSPLLGSF NE
