ID   Y910_MYCTU              Reviewed;         144 AA.
AC   P9WJ05; L0T7V9; O05902; Q7D942;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Toxin Rv0910;
GN   OrderedLocusNames=Rv0910;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   EXPRESSION IN M.SMEGMATIS, AND FUNCTION AS A TOXIN.
RC   STRAIN=ATCC 35801 / TMC 107 / Erdman;
RX   PubMed=20011113; DOI=10.1371/journal.pgen.1000767;
RA   Ramage H.R., Connolly L.E., Cox J.S.;
RT   "Comprehensive functional analysis of Mycobacterium tuberculosis toxin-
RT   antitoxin systems: implications for pathogenesis, stress responses, and
RT   evolution.";
RL   PLoS Genet. 5:E1000767-E1000767(2009).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Toxic component of a type II toxin-antitoxin (TA) system.
CC       Upon expression in M.smegmatis inhibits colony formation. Its toxic
CC       effect is neutralized by coexpression with cognate antitoxin Rv0909.
CC       Does not exert its toxic effect via translation.
CC       {ECO:0000269|PubMed:20011113}.
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DR   EMBL; AL123456; CCP43658.1; -; Genomic_DNA.
DR   PIR; F70581; F70581.
DR   RefSeq; NP_215425.1; NC_000962.3.
DR   RefSeq; WP_003404726.1; NZ_NVQJ01000001.1.
DR   AlphaFoldDB; P9WJ05; -.
DR   SMR; P9WJ05; -.
DR   STRING; 83332.Rv0910; -.
DR   PaxDb; P9WJ05; -.
DR   DNASU; 885137; -.
DR   GeneID; 45424873; -.
DR   GeneID; 885137; -.
DR   KEGG; mtu:Rv0910; -.
DR   TubercuList; Rv0910; -.
DR   eggNOG; COG3427; Bacteria.
DR   OMA; KPPEAMT; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0045926; P:negative regulation of growth; IMP:MTBBASE.
DR   Gene3D; 3.30.530.20; -; 1.
DR   InterPro; IPR019587; Polyketide_cyclase/dehydratase.
DR   InterPro; IPR023393; START-like_dom_sf.
DR   Pfam; PF10604; Polyketide_cyc2; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Toxin-antitoxin system.
FT   CHAIN           1..144
FT                   /note="Toxin Rv0910"
FT                   /id="PRO_0000406885"
SQ   SEQUENCE   144 AA;  15754 MW;  852217DB6D0D4E4A CRC64;
     MAKLSGSIDV PLPPEEAWMH ASDLTRYREW LTIHKVWRSK LPEVLEKGTV VESYVEVKGM
     PNRIKWTIVR YKPPEGMTLN GDGVGGVKVK LIAKVAPKEH GSVVSFDVHL GGPALLGPIG
     MIVAAALRAD IRESLQNFVT VFAG