Y9218_DICDI
ID Y9218_DICDI Reviewed; 1133 AA.
AC Q1ZXA9;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Uncharacterized protein DDB_G0292186;
GN ORFNames=DDB_G0292186;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP DISRUPTION PHENOTYPE.
RX PubMed=16507593; DOI=10.1242/jcs.02819;
RA Torija P., Vicente J.J., Rodrigues T.B., Robles A., Cerdan S., Sastre L.,
RA Calvo R.M., Escalante R.;
RT "Functional genomics in Dictyostelium: midA, a new conserved protein, is
RT required for mitochondrial function and development.";
RL J. Cell Sci. 119:1154-1164(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC {ECO:0000269|PubMed:16507593}.
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DR EMBL; AAFI02000187; EAS66813.1; -; Genomic_DNA.
DR RefSeq; XP_001134496.1; XM_001134496.1.
DR AlphaFoldDB; Q1ZXA9; -.
DR SMR; Q1ZXA9; -.
DR PaxDb; Q1ZXA9; -.
DR EnsemblProtists; EAS66813; EAS66813; DDB_G0292186.
DR GeneID; 8628515; -.
DR KEGG; ddi:DDB_G0292186; -.
DR dictyBase; DDB_G0292186; -.
DR eggNOG; KOG3661; Eukaryota.
DR HOGENOM; CLU_278794_0_0_1; -.
DR InParanoid; Q1ZXA9; -.
DR OMA; EVELYQT; -.
DR PRO; PR:Q1ZXA9; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0016540; P:protein autoprocessing; IBA:GO_Central.
DR Gene3D; 2.60.40.1390; -; 1.
DR InterPro; IPR026932; MYRF_ICA.
DR InterPro; IPR024061; NDT80_DNA-bd_dom.
DR InterPro; IPR037141; NDT80_DNA-bd_dom_sf.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR030392; S74_ICA.
DR Pfam; PF13887; MYRF_ICA; 1.
DR Pfam; PF05224; NDT80_PhoG; 1.
DR Pfam; PF13884; Peptidase_S74; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS51688; ICA; 1.
DR PROSITE; PS51517; NDT80; 1.
PE 4: Predicted;
KW DNA-binding; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1133
FT /note="Uncharacterized protein DDB_G0292186"
FT /id="PRO_0000371409"
FT TRANSMEM 1055..1075
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 909..1020
FT /note="Peptidase S74"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01025"
FT DNA_BIND 40..308
FT /note="NDT80"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00850"
FT REGION 33..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 305..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 679..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1107..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..629
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 736..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 753..771
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 908..909
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01025"
SQ SEQUENCE 1133 AA; 126283 MW; 59E34BD7FEF55E3D CRC64;
MLGLFNNSNS INGSGNNQDI DEIKREQMSN FDQFEDGLNN NNSNNNNNNN NSNNNNSNNN
ENINRKTGST LLSSSTSQLN SSSGQISFSK DAVAPTKKRR YIVDKDHIFS WTPYCKAYWN
KLINVYGVEL EPPQLNVSAE KGFSFSEVDN SWIYYRRNHF QLGIGVSHCF QFLESSPPLI
SLNGSIYPVD DFYLCIRGVK NGPDVNINEE VEVELYQTNS KREKGEEKLP PPVLMTFSTN
VTIPRLHFRK ATANNARKHK LPNPQQEFFR LVLTVVARAQ SRDFCITSMI SDPLIVRTGH
PTCNPVSNNP STPGTPISNF DSSNNNNSSS SSSIINNNNN GISGYSPHTT VTTNSTTIIP
TYGSGNNNNN NNNNNNNSSG NSSSTSPMVG PLGVVFPPSP INSLSNHNSP HLTPIQYNNN
NNNSNNNSNN NNNNNNNNNN SNNNNNNSNN NNHQFQSNNR IFKGNLSNPF DLNYSQNSNN
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNI FSHNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNNNNNSQ NIHFYNNNSN NNNNNNSSSS NNNNNNNNNN
NNNNNKNNNN NGNNSQINEK HNLSSNSNSS GFTAELFSSI ENTIRNNNFL TQKPHFPFDQ
TLHQLQFQAQ NNQYDQINGK LDNIHNNSNN NSSNNNNSNN NSSNNNSNNN NNNNGSHTAS
VKRKLSNSYD QQNLEIESPQ SYISSPTPYF VDNKQPQPQP QPQPQPQPQP QPQSQSQSQS
QSQSQSQSQS QSQSQPIQQI VQQQLSSPTQ FSQSEEVILS SPLQQQTIQS IQQQQPQQQV
ITNPLLQQPQ QQQQNIISIG DMDKNIKWAQ SPNGGLFHFG NVGVNSENPQ EALSVNGNVS
ISGMMYQPSD KRVKENVKPV NSKDQLSNIM KLKIYDYQLT DEWVKSQNLT ETKDRGVLAQ
DLNTPSNHIP NSVKHTGDRI LGNGRVIKDF LVVNKDAIFL ENVGATQELS KKVDNVCMEL
ETLDKKKFEM LGHKMSELER TTIREIKKNQ KRKKIFIGIG VFTLFVIFGL VAVSIVLGTR
NTITKNITVY TTGSPGYLNG DCTDSESGSN SCYDSSSNSA IDTTTSTGSG SIK
