ID   Y921_CHLMU              Reviewed;         529 AA.
AC   Q9PJB1;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=UPF0159 protein TC_0921;
GN   OrderedLocusNames=TC_0921;
OS   Chlamydia muridarum (strain MoPn / Nigg).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=243161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MoPn / Nigg;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
CC   -!- SIMILARITY: Belongs to the UPF0159 family. {ECO:0000305}.
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DR   EMBL; AE002160; AAF39712.1; -; Genomic_DNA.
DR   PIR; H81650; H81650.
DR   RefSeq; WP_010231946.1; NZ_CP027217.1.
DR   AlphaFoldDB; Q9PJB1; -.
DR   STRING; 243161.TC_0921; -.
DR   EnsemblBacteria; AAF39712; AAF39712; TC_0921.
DR   GeneID; 1246291; -.
DR   KEGG; cmu:TC_0921; -.
DR   eggNOG; COG1351; Bacteria.
DR   HOGENOM; CLU_024745_0_0_0; -.
DR   OMA; MHRHRRC; -.
DR   OrthoDB; 809519at2; -.
DR   Proteomes; UP000000800; Chromosome.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0050797; F:thymidylate synthase (FAD) activity; IEA:InterPro.
DR   GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.30.1360.170; -; 2.
DR   InterPro; IPR003669; Thymidylate_synthase_ThyX.
DR   InterPro; IPR036098; Thymidylate_synthase_ThyX_sf.
DR   PANTHER; PTHR34934; PTHR34934; 1.
DR   Pfam; PF02511; Thy1; 2.
DR   SUPFAM; SSF69796; SSF69796; 2.
DR   PROSITE; PS51331; THYX; 2.
PE   3: Inferred from homology;
KW   Repeat.
FT   CHAIN           1..529
FT                   /note="UPF0159 protein TC_0921"
FT                   /id="PRO_0000220642"
FT   DOMAIN          38..274
FT                   /note="ThyX 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00661"
FT   DOMAIN          309..511
FT                   /note="ThyX 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00661"
SQ   SEQUENCE   529 AA;  60780 MW;  C00E72249D975ED5 CRC64;
     MLSKEGDFSK EQRERLSHFV TNLDSPIFAL KNLPEVVKGA LFSKYSRSIL GLRALLLKEF
     LDGEGGDFLS EDLQDCELGI QKAADFYRRV LDNFGDDSVG ELGGAHLAIE QVSMLAAKVL
     EDARIGGSPL EKSSRYVYFD QKVNGEYLYY RDPILMTSAF KDTFLDTCDF LFNTYSELIP
     QVRAYFEKIY PKDPEVSQSA YTVSLRAKVL DCLRGLLPAA TLTNLGFFGN GRFWQNLLHR
     LQDNNLVEVR NIGEQALTEL MKIIPSFVSR AEPHHHHHQA MVDYHLGLRE QLKSFAQRYG
     EEREPSLEKG VKLVYGDPDG LYKIAAASMF PYSEHTYADL LDICRKIPDE DLMLILESSA
     SSRENRRHKS PRGLECAEFA FDITADFGAY RDLQRHRILT QERQLLTTKL GYSIPQQLLD
     TPMEAPFREA MEKADQAYRL IAAEFPEEAQ YVVPLAYNIR WLFHINTRGL QWLCELRSQP
     QGHESYRQIA IDMAKEVIQF HPAYKSFLKF VDYSETDLGR LKQESRRKA