CATA2_SOLTU
ID CATA2_SOLTU Reviewed; 492 AA.
AC P55312;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Catalase isozyme 2;
DE EC=1.11.1.6;
GN Name=CAT2;
OS Solanum tuberosum (Potato).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum.
OX NCBI_TaxID=4113;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-492.
RC STRAIN=cv. Datura; TISSUE=Leaf;
RX PubMed=7655060; DOI=10.1094/mpmi-8-0371;
RA Niebel A., Heungens K., Barthels N., Inze D., van Montagu M., Gheysen G.;
RT "Characterization of a pathogen-induced potato catalase and its systemic
RT expression upon nematode and bacterial infection.";
RL Mol. Plant Microbe Interact. 8:371-378(1995).
CC -!- FUNCTION: Occurs in almost all aerobically respiring organisms and
CC serves to protect cells from the toxic effects of hydrogen peroxide.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6;
CC Evidence={ECO:0000255|PROSITE-ProRule:PRU10013};
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413;
CC -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000250}. Glyoxysome
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the catalase family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z37106; CAA85470.1; -; Genomic_DNA.
DR AlphaFoldDB; P55312; -.
DR SMR; P55312; -.
DR IntAct; P55312; 1.
DR STRING; 4113.PGSC0003DMT400075611; -.
DR PRIDE; P55312; -.
DR ProMEX; P55312; -.
DR eggNOG; KOG0047; Eukaryota.
DR InParanoid; P55312; -.
DR Proteomes; UP000011115; Unassembled WGS sequence.
DR ExpressionAtlas; P55312; baseline.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0009514; C:glyoxysome; IEA:UniProtKB-SubCell.
DR GO; GO:0005777; C:peroxisome; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004096; F:catalase activity; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR GO; GO:0042542; P:response to hydrogen peroxide; IBA:GO_Central.
DR InterPro; IPR018028; Catalase.
DR InterPro; IPR024708; Catalase_AS.
DR InterPro; IPR024711; Catalase_clade1/3.
DR InterPro; IPR011614; Catalase_core.
DR InterPro; IPR002226; Catalase_haem_BS.
DR InterPro; IPR010582; Catalase_immune_responsive.
DR InterPro; IPR020835; Catalase_sf.
DR PANTHER; PTHR11465; PTHR11465; 1.
DR Pfam; PF00199; Catalase; 1.
DR Pfam; PF06628; Catalase-rel; 1.
DR PIRSF; PIRSF038928; Catalase_clade1-3; 1.
DR PRINTS; PR00067; CATALASE.
DR SMART; SM01060; Catalase; 1.
DR SUPFAM; SSF56634; SSF56634; 1.
DR PROSITE; PS00437; CATALASE_1; 1.
DR PROSITE; PS00438; CATALASE_2; 1.
DR PROSITE; PS51402; CATALASE_3; 1.
PE 3: Inferred from homology;
KW Glyoxysome; Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase;
KW Peroxidase; Peroxisome; Reference proteome.
FT CHAIN 1..492
FT /note="Catalase isozyme 2"
FT /id="PRO_0000084962"
FT ACT_SITE 65
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"
FT ACT_SITE 138
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"
FT BINDING 348
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
SQ SEQUENCE 492 AA; 56451 MW; 5C84E2C381F2C140 CRC64;
MDPSKYRPSS AYDTPFLTTN AGGPVYNNVS SLTVGPRGPV LLEDYYLIEK LATFDREKIP
ERVVHARGAS AKGFFEVTHD ISHLTCADFL RAPGAQTPVI CRFSTVVHER GSPESIRDIR
GFAVKFYTRE GNFDLVGNNV PVFFNRDAKS FPDTIRALKP NPKSHIQENW RILDFFSFLP
ESLHTFAFFY DDVCLPTDYR HMEGFGVHAY QLINKEGKAH YVKFHWKPTC GVKSMSEEEA
IRVGGTNHSH ATKDLYDSIA AGNYPEWKLF IQTMDPEDVD KFDFDPLDVT KTWPEDLLPL
IPVGRLVLNR NIDNFFAENE QLAFNPGHIV PGIYYSEDKL LQTRIFAYAD TQRHRIGPNY
MQLPVNAPKC GHHNNHRDGA MNMTHRDEEV DYLPSRFDPC RPAEQYPIPA CVLNGRRTNC
VIPKENNFKQ AGERYRSWES DRQDRYITKW VESLSDPRVT HEIRSIWISY LSQADKSCGQ
KVASRLTVKP TM