ID   Y927C_MYCTO             Reviewed;         263 AA.
AC   P9WGQ4; L0T570; O05919; Q7D928;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Uncharacterized oxidoreductase MT0954;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=MT0954;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK45201.1; -; Genomic_DNA.
DR   PIR; G70583; G70583.
DR   RefSeq; WP_003404769.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WGQ4; -.
DR   SMR; P9WGQ4; -.
DR   EnsemblBacteria; AAK45201; AAK45201; MT0954.
DR   GeneID; 45424893; -.
DR   KEGG; mtc:MT0954; -.
DR   PATRIC; fig|83331.31.peg.1024; -.
DR   HOGENOM; CLU_010194_1_3_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Oxidoreductase.
FT   CHAIN           1..263
FT                   /note="Uncharacterized oxidoreductase MT0954"
FT                   /id="PRO_0000428321"
FT   ACT_SITE        160
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         17..41
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         147
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         164
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   263 AA;  26746 MW;  544AB32F709D97E3 CRC64;
     MILDMFRLDD KVAVITGGGR GLGAAIALAF AQAGADVLIA SRTSSELDAV AEQIRAAGRR
     AHTVAADLAH PEVTAQLAGQ AVGAFGKLDI VVNNVGGTMP NTLLSTSTKD LADAFAFNVG
     TAHALTVAAV PLMLEHSGGG SVINISSTMG RLAARGFAAY GTAKAALAHY TRLAALDLCP
     RVRVNAIAPG SILTSALEVV AANDELRAPM EQATPLRRLG DPVDIAAAAV YLASPAGSFL
     TGKTLEVDGG LTFPNLDLPI PDL