ID   Y927C_MYCTU             Reviewed;         263 AA.
AC   P9WGQ5; L0T570; O05919; Q7D928;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Uncharacterized oxidoreductase Rv0927c;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Rv0927c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43675.1; -; Genomic_DNA.
DR   PIR; G70583; G70583.
DR   RefSeq; NP_215442.1; NC_000962.3.
DR   RefSeq; WP_003404769.1; NZ_NVQJ01000001.1.
DR   AlphaFoldDB; P9WGQ5; -.
DR   SMR; P9WGQ5; -.
DR   STRING; 83332.Rv0927c; -.
DR   PaxDb; P9WGQ5; -.
DR   DNASU; 885571; -.
DR   GeneID; 45424893; -.
DR   GeneID; 885571; -.
DR   KEGG; mtu:Rv0927c; -.
DR   TubercuList; Rv0927c; -.
DR   eggNOG; COG1028; Bacteria.
DR   OMA; FPTKGAW; -.
DR   PhylomeDB; P9WGQ5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0052559; P:induction by symbiont of host immune response; IDA:MTBBASE.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   1: Evidence at protein level;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..263
FT                   /note="Uncharacterized oxidoreductase Rv0927c"
FT                   /id="PRO_0000415507"
FT   ACT_SITE        160
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         17..41
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
FT   BINDING         147
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         164
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   263 AA;  26746 MW;  544AB32F709D97E3 CRC64;
     MILDMFRLDD KVAVITGGGR GLGAAIALAF AQAGADVLIA SRTSSELDAV AEQIRAAGRR
     AHTVAADLAH PEVTAQLAGQ AVGAFGKLDI VVNNVGGTMP NTLLSTSTKD LADAFAFNVG
     TAHALTVAAV PLMLEHSGGG SVINISSTMG RLAARGFAAY GTAKAALAHY TRLAALDLCP
     RVRVNAIAPG SILTSALEVV AANDELRAPM EQATPLRRLG DPVDIAAAAV YLASPAGSFL
     TGKTLEVDGG LTFPNLDLPI PDL