Y9332_DICDI
ID Y9332_DICDI Reviewed; 614 AA.
AC Q55E98;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Probable zinc transporter protein DDB_G0269332;
GN ORFNames=DDB_G0269332;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May be involved in zinc transport from the cytoplasm to
CC either intracellular organelles or extracellular spaces. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000005; EAL72016.1; -; Genomic_DNA.
DR RefSeq; XP_645883.1; XM_640791.1.
DR AlphaFoldDB; Q55E98; -.
DR SMR; Q55E98; -.
DR STRING; 44689.DDB0266645; -.
DR PaxDb; Q55E98; -.
DR EnsemblProtists; EAL72016; EAL72016; DDB_G0269332.
DR GeneID; 8616823; -.
DR KEGG; ddi:DDB_G0269332; -.
DR dictyBase; DDB_G0269332; zntC.
DR eggNOG; KOG1484; Eukaryota.
DR HOGENOM; CLU_445120_0_0_1; -.
DR InParanoid; Q55E98; -.
DR OMA; EIFYGAY; -.
DR Reactome; R-DDI-264876; Insulin processing.
DR Reactome; R-DDI-435368; Zinc efflux and compartmentalization by the SLC30 family.
DR PRO; PR:Q55E98; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IDA:dictyBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0055037; C:recycling endosome; IDA:dictyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046873; F:metal ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0006882; P:cellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR GO; GO:1904257; P:zinc ion import into Golgi apparatus; IBA:GO_Central.
DR Gene3D; 1.20.1510.10; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR002395; Kininogen.
DR InterPro; IPR045316; Msc2-like.
DR PANTHER; PTHR45755; PTHR45755; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR PRINTS; PR00334; KININOGEN.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 3: Inferred from homology;
KW Ion transport; Membrane; Metal-binding; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..614
FT /note="Probable zinc transporter protein DDB_G0269332"
FT /id="PRO_0000385371"
FT TOPO_DOM 1..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..233
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..306
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 307..327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..351
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 373..377
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 399..614
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 586..603
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 614 AA; 70025 MW; 835A0436DAA5B959 CRC64;
MSDINSNSYD PYHHPQQHQQ ESQYHPQQQQ QQQQQQQQQQ EYYNQQHQQE SQYQQQSPPQ
QQYDNHQHHQ QDLNQAHNSG HGRSHNSGHG HSHGNNYSGL PHLRTQVGHA QPYFSSYNEL
NNSGDISNSN NNNNNNNQYN YNNNNNNNNY NNNINNNQFN SSVYNNNNNN NNNNNNEFSI
DGKSGITIKH LLNNLNRDSD AKKLAAWISV MLVFTIYEIF YGAYLESLGL VSDGFHALFD
CIGMGIALLA MLVGKRGISN QEYTYGYDRW EVLGTFSNGC FLLFVSFFLF LESIERLLEP
PHIHNHGRVM SLATISLIIN IVGVLFFKQK SNERKQQSSI RSENLLTISH HILVDSCTSL
GVILSSLVGQ AFGLEISDSL ISIIIACIIV YNALPICIKT SAILLQTTPD QLKININNAI
KDILVMEGVI DVTDKHFWSH SPGNIIATVN LLTKKNCDDF TLTQSIRNRL SFVQDLTIQL
DKEGKHNSHS HGGAHHHPHE HKEDKKSHNH SHGHNHGHSH GHSHGGNDDH EHGENCDEEH
EPVPKYQVQP TSPFSSHYTD IHSNNTPIPL YKSEQDDEDD EDDYDHDEHH HDHDHDEHHH
GHSHNSSHSH AHNH
