ID   Y945_MYCTU              Reviewed;         253 AA.
AC   P9WGR7; L0T7Z5; P71564;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Uncharacterized oxidoreductase Rv0945;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Rv0945; ORFNames=MTCY10D7.29c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP43693.1; -; Genomic_DNA.
DR   PIR; G70715; G70715.
DR   RefSeq; NP_215460.1; NC_000962.3.
DR   RefSeq; WP_003898658.1; NC_018143.2.
DR   AlphaFoldDB; P9WGR7; -.
DR   SMR; P9WGR7; -.
DR   STRING; 83332.Rv0945; -.
DR   PaxDb; P9WGR7; -.
DR   DNASU; 885629; -.
DR   GeneID; 885629; -.
DR   KEGG; mtu:Rv0945; -.
DR   PATRIC; fig|83332.111.peg.1046; -.
DR   TubercuList; Rv0945; -.
DR   eggNOG; COG4221; Bacteria.
DR   OMA; RAMTVYA; -.
DR   PhylomeDB; P9WGR7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   1: Evidence at protein level;
KW   Oxidoreductase; Reference proteome.
FT   CHAIN           1..253
FT                   /note="Uncharacterized oxidoreductase Rv0945"
FT                   /id="PRO_0000054862"
FT   ACT_SITE        159
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT   BINDING         145
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   253 AA;  27139 MW;  BAD937208842DA12 CRC64;
     MLTGVTRQKI LITGASSGLG AGMARSFAAQ GRDLALCARR TDRLTELKAE LSQRYPDIKI
     AVAELDVNDH ERVPKVFAEL SDEIGGIDRV IVNAGIGKGA RLGSGKLWAN KATIETNLVA
     ALVQIETALD MFNQRGSGHL VLISSVLGVK GVPGVKAAYA ASKAGVRSLG ESLRAEYAQR
     PIRVTVLEPG YIESEMTAKS ASTMLMVDNA TGVKALVAAI EREPGRAAVP WWPWAPLVRL
     MWVLPPRLTR RFA