Y9517_DICDI
ID Y9517_DICDI Reviewed; 712 AA.
AC Q54HD9;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 60.
DE RecName: Full=Follistatin-like domain-containing protein DDB_G0289517;
DE Flags: Precursor;
GN ORFNames=DDB_G0289517;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP DEVELOPMENTAL STAGE [LARGE SCALE ANALYSIS].
RX PubMed=12796308; DOI=10.1128/ec.2.3.627-637.2003;
RA Maeda M., Sakamoto H., Iranfar N., Fuller D., Maruo T., Ogihara S.,
RA Morio T., Urushihara H., Tanaka Y., Loomis W.F.;
RT "Changing patterns of gene expression in Dictyostelium prestalk cell
RT subtypes recognized by in situ hybridization with genes from microarray
RT analyses.";
RL Eukaryot. Cell 2:627-637(2003).
RN [3]
RP DEVELOPMENTAL STAGE [LARGE SCALE ANALYSIS].
RX PubMed=16107728; DOI=10.1128/mcb.25.17.7839-7853.2005;
RA Mendoza M.C., Du F., Iranfar N., Tang N., Ma H., Loomis W.F., Firtel R.A.;
RT "Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell
RT polarity, chemotaxis, and gene expression defects.";
RL Mol. Cell. Biol. 25:7839-7853(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed in prestalk cells only during
CC culmination and not at the slug stage. Expressed at high levels in pstO
CC cells. Expressed precociously in mekA and erkA-null cells during early
CC development. Precocious expression completely depends on the presence
CC of smkA. {ECO:0000269|PubMed:12796308, ECO:0000269|PubMed:16107728}.
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DR EMBL; AAFI02000141; EAL62690.1; -; Genomic_DNA.
DR RefSeq; XP_636199.1; XM_631107.1.
DR AlphaFoldDB; Q54HD9; -.
DR STRING; 44689.DDB0231081; -.
DR PaxDb; Q54HD9; -.
DR PRIDE; Q54HD9; -.
DR EnsemblProtists; EAL62690; EAL62690; DDB_G0289517.
DR GeneID; 8627186; -.
DR KEGG; ddi:DDB_G0289517; -.
DR dictyBase; DDB_G0289517; -.
DR eggNOG; ENOG502RCBQ; Eukaryota.
DR HOGENOM; CLU_388036_0_0_1; -.
DR InParanoid; Q54HD9; -.
DR OMA; SHEWCLK; -.
DR PRO; PR:Q54HD9; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031160; C:spore wall; IEA:UniProt.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProt.
DR InterPro; IPR007643; Dict_spore_N.
DR InterPro; IPR003645; Fol_N.
DR Pfam; PF04562; Dicty_spore_N; 1.
DR SMART; SM00274; FOLN; 5.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..712
FT /note="Follistatin-like domain-containing protein
FT DDB_G0289517"
FT /id="PRO_0000392664"
FT DOMAIN 399..421
FT /note="Follistatin-like 1"
FT DOMAIN 471..494
FT /note="Follistatin-like 2"
FT DOMAIN 596..618
FT /note="Follistatin-like 3"
FT DOMAIN 660..682
FT /note="Follistatin-like 4"
FT DOMAIN 687..710
FT /note="Follistatin-like 5"
FT REGION 181..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 217
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 234
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 369
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 407
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 505
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 524
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 566
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 622
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 712 AA; 81422 MW; 45EB030C96E91797 CRC64;
MKIQTIIQIV LISFLFLNVE SKKINCLHLQ QDECIKNKDK CFLSNVNSCC EKDFLMCLPI
SSKYCESQTD DVFSNKNILK KSPPSSSHEW CLKKKKSILR FNTSCVPELD LDSEYFKPNL
YKCKYSKCQK GFKCVDEKLH KKCETENNPC CKYESKCVPS KDIDQNEAPI FKNPKGQLAQ
DIYNHLNPDS PQFKDKPNHE NHKKDKNNKK HKKDIKNNSD KNNNNNNNNN NKKNKTINNN
EPNQNQQSNP IDRTFNNETP FPWNFKNQDQ QQQKQEQTQK QTQKEYFKAG SPYPVLPNLN
KEPTTHLNTI EPTSFTASAS RYQLEGNDNK DEENIDENNG EDKKKKKKKK KDDKSKKPKD
DEKHTKKPNV TEQPADDPSI EITEEPTITP SSSPVHQDPC KKATCPNGSH CLVYGNQAYC
KLDKPPNYQT MSPLPQKQQP SVKKMDSLSM FYKKSKMLLS EYTTEQRPQL TCSTIKCEDD
EVCINKVGLN PYCQIKPPPK PVSYNKTSCS QCPIGSYRCN PNPNGSGVIC ETDAINCRLI
ACKEGEFCID NIENTPPKCY PKLLCNLSKI PPDYYCISDE IRGGFYVKYE SYIDLSCETL
LCEGVNSYCV ENGGPICKTW PNDTIQYQPS CDKCPKDTMS CTPNENSNNK GVVCRIDRPS
CSVIQCPDNQ YCVNTDKGPK CYKRSIECSN SRCPRDYTCK RDEIRGGACL KN
