ID   CATA_BLUHO              Reviewed;         718 AA.
AC   Q8X1P0;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Catalase;
DE            EC=1.11.1.6;
GN   Name=CAT1;
OS   Blumeria hordei (Barley powdery mildew) (Blumeria graminis f. sp. hordei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Erysiphales; Erysiphaceae; Blumeria.
OX   NCBI_TaxID=2867405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Zhang Z., Gurr S.J.;
RT   "Isolation and characterization of a Blumeria graminis catalase gene
RT   involved in antioxidant action in barley/powdery mildew interactions.";
RL   Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Occurs in almost all aerobically respiring organisms and
CC       serves to protect cells from the toxic effects of hydrogen peroxide.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H2O2 = 2 H2O + O2; Xref=Rhea:RHEA:20309, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15379, ChEBI:CHEBI:16240; EC=1.11.1.6;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU10013};
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC   -!- SIMILARITY: Belongs to the catalase family. {ECO:0000305}.
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DR   EMBL; AF327335; AAL56982.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8X1P0; -.
DR   SMR; Q8X1P0; -.
DR   PRIDE; Q8X1P0; -.
DR   GO; GO:0004096; F:catalase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR   CDD; cd03132; GATase1_catalase; 1.
DR   Gene3D; 1.20.1370.20; -; 1.
DR   Gene3D; 3.40.50.880; -; 1.
DR   InterPro; IPR018028; Catalase.
DR   InterPro; IPR024708; Catalase_AS.
DR   InterPro; IPR024712; Catalase_clade2.
DR   InterPro; IPR043156; Catalase_clade2_helical.
DR   InterPro; IPR011614; Catalase_core.
DR   InterPro; IPR010582; Catalase_immune_responsive.
DR   InterPro; IPR041399; Catalase_large_C.
DR   InterPro; IPR020835; Catalase_sf.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   PANTHER; PTHR42821; PTHR42821; 1.
DR   Pfam; PF00199; Catalase; 1.
DR   Pfam; PF06628; Catalase-rel; 1.
DR   Pfam; PF18011; Catalase_C; 1.
DR   PIRSF; PIRSF038927; Catalase_clade2; 1.
DR   PRINTS; PR00067; CATALASE.
DR   SMART; SM01060; Catalase; 1.
DR   SUPFAM; SSF56634; SSF56634; 1.
DR   PROSITE; PS00438; CATALASE_2; 1.
DR   PROSITE; PS51402; CATALASE_3; 1.
PE   3: Inferred from homology;
KW   Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase.
FT   CHAIN           1..718
FT                   /note="Catalase"
FT                   /id="PRO_0000084922"
FT   ACT_SITE        103
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"
FT   ACT_SITE        176
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU10013"
FT   BINDING         390
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   718 AA;  79011 MW;  31F4135D69A42544 CRC64;
     MRLSLWNLLG LSGLVVASCP YMSGEDQEYH ISHIQARGTD SEFLDQFKVE DSNSYLTTDA
     GGPIQDDASL KAGERGPTLL EDFIFRQKIQ HFDHERVPER AVHARGAGAY GTFTSYADWT
     NITAASFLNS KGKETPVFVR FSTVAGSRGS ADTVRDVHGF ATRFYTDEGN FDIVGNNIPV
     FFIQDAILFP DLVHAVKPSP DSEIPQAATG HDSAWDFFSQ QPSTLHTLFW AMSGHGIPRS
     YRHMDGFGVH TMRLVTDDGK SKLVKWHWKT KQGKASLVWE EAQILAGKNP DFHRQDLWDD
     INAGNGPEWE LGVQIVDEED VQAFGFDLLD PTKFLPEELV PVTILGKMKL TDNPTNYFAE
     TEQVMFQPGH IVRGVDFSDD PLLQGRIYSY LDTQLNRNGG PNFEQLPVNR PRTKVHNNNR
     DGAGQMFIHT NKAPYSPNSL SGGNPKQANQ TKGRGFFTAP SRKVVGSLHR GTASSFADVW
     SQPRMFYNSL IPSEQQFLVN AIRFEISQLK SDLIKKNTLM QLNRVSNDLA TRVAAVIGYK
     PLDPSPEFYT NATTDYVTIF GKPLPSVVGF TVGILASTSS STSISQAAQL ATSFSSRGIR
     AVIVGESLLS GTDQTYSSAD ATAFDAVVVT MGAETLFGPV AKPNTLFPSG RPSQILHDAY
     RWGKPVGAVS KASVVLEPLP GTKNQGGVYR VESVNELATS IAKGLETFRF VDRFPLDS