ID   Y956_HELPY              Reviewed;         242 AA.
AC   O25610;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Uncharacterized RNA pseudouridine synthase HP_0956;
DE            EC=5.4.99.-;
DE   AltName: Full=RNA pseudouridylate synthase;
DE   AltName: Full=RNA-uridine isomerase;
GN   OrderedLocusNames=HP_0956;
OS   Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=85962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700392 / 26695;
RX   PubMed=9252185; DOI=10.1038/41483;
RA   Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA   Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA   Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA   Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA   McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA   Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA   Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA   Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT   "The complete genome sequence of the gastric pathogen Helicobacter
RT   pylori.";
RL   Nature 388:539-547(1997).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a pseudouridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
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DR   EMBL; AE000511; AAD07999.1; -; Genomic_DNA.
DR   PIR; D64639; D64639.
DR   RefSeq; NP_207748.1; NC_000915.1.
DR   RefSeq; WP_000409617.1; NC_018939.1.
DR   AlphaFoldDB; O25610; -.
DR   SMR; O25610; -.
DR   IntAct; O25610; 2.
DR   STRING; 85962.C694_04925; -.
DR   PaxDb; O25610; -.
DR   EnsemblBacteria; AAD07999; AAD07999; HP_0956.
DR   KEGG; hpy:HP_0956; -.
DR   PATRIC; fig|85962.47.peg.1024; -.
DR   eggNOG; COG0564; Bacteria.
DR   OMA; QFEHREV; -.
DR   PhylomeDB; O25610; -.
DR   Proteomes; UP000000429; Chromosome.
DR   GO; GO:0140098; F:catalytic activity, acting on RNA; IEA:UniProt.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IBA:GO_Central.
DR   CDD; cd02869; PseudoU_synth_RluA_like; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
DR   PROSITE; PS50889; S4; 1.
PE   3: Inferred from homology;
KW   Isomerase; Reference proteome; RNA-binding.
FT   CHAIN           1..242
FT                   /note="Uncharacterized RNA pseudouridine synthase HP_0956"
FT                   /id="PRO_0000162737"
FT   DOMAIN          2..62
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00182"
FT   ACT_SITE        93
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   242 AA;  27457 MW;  BB94C062C7BE8165 CRC64;
     MEKAYKILSV QENISHKKAK ALIDSGLVSI GGKKLMVARK ELPKNTHFSV QKVEKPSVIF
     EDENILALFK PPFIESYDLA SFFKGWALLH RLDKETSGVV LLVKENSEFH LKAKKAFKDR
     AVKKEYLALT QGIIEEEREI NAPILTFKTT KAFSKISKKG QEAVTIITPL KIINKKTLLK
     VGIKTGRTHQ IRVHLKHINH PIIGDTLYNN EPSLAKRLML HAHKIALLGY EFEAIAPKEF
     EI