ID   Y9609_DICDI             Reviewed;         419 AA.
AC   Q54WK1;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Putative actin-fragmin kinase DDB_G0279609;
GN   ORFNames=DDB_G0279609;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA   Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT   "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT   model organism.";
RL   PLoS Genet. 2:E38-E38(2006).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=12963116; DOI=10.1016/s0925-4773(03)00136-9;
RA   Muramoto T., Suzuki K., Shimizu H., Kohara Y., Kohriki E., Obara S.,
RA   Tanaka Y., Urushihara H.;
RT   "Construction of a gamete-enriched gene pool and RNAi-mediated functional
RT   analysis in Dictyostelium discoideum.";
RL   Mech. Dev. 120:965-975(2003).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=15817229; DOI=10.1016/j.mod.2004.11.015;
RA   Muramoto T., Takeda S., Furuya Y., Urushihara H.;
RT   "Reverse genetic analyses of gamete-enriched genes revealed a novel
RT   regulator of the cAMP signaling pathway in Dictyostelium discoideum.";
RL   Mech. Dev. 122:733-743(2005).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. AFK Ser/Thr
CC       protein kinase family. {ECO:0000305}.
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DR   EMBL; AAFI02000032; EAL67579.1; -; Genomic_DNA.
DR   RefSeq; XP_641552.1; XM_636460.1.
DR   AlphaFoldDB; Q54WK1; -.
DR   SMR; Q54WK1; -.
DR   STRING; 44689.DDB0231760; -.
DR   PaxDb; Q54WK1; -.
DR   EnsemblProtists; EAL67579; EAL67579; DDB_G0279609.
DR   GeneID; 8622126; -.
DR   KEGG; ddi:DDB_G0279609; -.
DR   dictyBase; DDB_G0279609; -.
DR   eggNOG; ENOG502SGQR; Eukaryota.
DR   HOGENOM; CLU_054301_0_0_1; -.
DR   InParanoid; Q54WK1; -.
DR   OMA; TIVQEVY; -.
DR   PhylomeDB; Q54WK1; -.
DR   PRO; PR:Q54WK1; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   GO; GO:0019953; P:sexual reproduction; IEP:dictyBase.
DR   CDD; cd05124; AFK; 1.
DR   Gene3D; 1.10.1070.11; -; 1.
DR   InterPro; IPR015275; Actin-fragmin_kin_cat_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR037469; Put_AFK.
DR   PANTHER; PTHR38737; PTHR38737; 1.
DR   Pfam; PF09192; Act-Frag_cataly; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   Kinase; Reference proteome; Transferase.
FT   CHAIN           1..419
FT                   /note="Putative actin-fragmin kinase DDB_G0279609"
FT                   /id="PRO_0000367583"
FT   REGION          73..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   419 AA;  48297 MW;  BB3C134EBD659595 CRC64;
     MNKIKVFKKN FFFEKIKNKK NNIEIKKSTN DSTSNTCTDI KNNIIIENKI NEENIENNNN
     INIGNNSVNN NNINNNNNSI NNNNNNNNKN KNKNNNSYIP MIQYSNIHCI DWSSLISVDK
     LDLGSSNIFL IATFLNNKCE YNQVLLKSST TIVQEVYASV LESILKLPIP EMRLLEYSND
     EYIQMSRSLL TISSKTNKSL YDYIKLELLK SFFLIMEYAP NGKSFKDLDY KEYFSGYGGE
     KKLNQLGQVI AFDIFCNNSD RLPLIWDNVS SHFSNILFYD IPNRNGWYIS LMNSNVTCIN
     NSSFTIGYRK YITRVKSILY ALFKRPNIES NQIKKMRESI SKSYKINLSS SCGISIQRGI
     IQGVQLIISR ISISILSDTK EKLRHLVKVD STTNAWKKGL DSIHLPFLSD LLDTMVLFY